TRIM28 / KAP1

tripartite motif containing 28

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

TRIM28 / KAP1 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human TRIM28 / KAP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68131

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

88.4 kDa

Price:

20 µg/$1,107

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Human TRIM28 / KAP1 Protein (Recombinant His) - LS-G2549

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human TRIM28 / KAP1 Protein (Recombinant GST, N-terminus) (aa379-524) - LS-G61395

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TRIM28 / KAP1 Protein (Recombinant His, N-Terminal) (Pro504-Ile785) - LS-G133169

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

33.1kDa

Price:

10 µg/$243; 50 µg/$291; 200 µg/$402; 100 µg/$339; 1 mg/$1,156; 500 µg/$802; 5 mg/$1,982; 2 mg/$1,298

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Mouse TRIM28 / KAP1 Protein (Recombinant His, N-Terminal) (Pro504-Ala820) - LS-G133206

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

37.1kDa

Price:

10 µg/$247; 50 µg/$303; 200 µg/$462; 100 µg/$370; 1 mg/$1,284; 500 µg/$922; 5 mg/$2,151; 2 mg/$1,437

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Human TRIM28 / KAP1 Protein (Recombinant GST) (Full Length) - LS-G31985

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

114.9 kDa

Price:

10 µg/$479; 25 µg/$670

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TRIM28 / KAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115750

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

88.4 kDa

Price:

100 µg/$494

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Human TRIM28 / KAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81512

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

88.4 kDa

Price:

20 µg/$150

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