TEC

tec protein tyrosine kinase

Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation.

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Proteins (7)

Type

Over-Expression Lysate (3)

Recombinant (4)

Target

TEC (7)

Publications

No (7)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-T7 (2)

Myc-DDK (Flag) (2)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human TEC Protein (Recombinant His, N-Terminal) - LS-G144293

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

73.4 kDa

Price:

50 µg/$419

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Human TEC Protein (Recombinant His-T7) (aa370-623) - LS-G25095

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.3 kDa

Price:

10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646

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Human TEC Protein (Recombinant GST, N-terminus) (aa311-410) - LS-G60315

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse TEC Protein (Recombinant His-T7) (aa369-622) - LS-G25096

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.4 kDa

Price:

10 µg/$270; 50 µg/$372; 100 µg/$592; 200 µg/$742; 1 mg/$1,786; 500 µg/$1,352; 5 mg/$2,742; 2 mg/$1,966

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Human TEC Protein (Over-Expression Lysate 6His, N-terminus) (Asn2-Arg631) - LS-G26812

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

76 kDa

Price:

100 µg/$298

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TEC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117485

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.4 kDa

Price:

100 µg/$494

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Human TEC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79409

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.4 kDa

Price:

20 µg/$150

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