SHH / Sonic Hedgehog

sonic hedgehog

SHH / Sonic Hedgehog is a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

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Products

ELISA Kits (26)

Type

Competitive EIA (1)

Custom (4)

Development Kit (1)

Sandwich (17)

Sandwich CLIA (3)

Target

SHH / Sonic Hedgehog (26)

Reactivity

Human (9)

Mouse (6)

Rat (7)

Chicken (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Product Group

DevKit DuoPlus (1)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (6)

96-Well Strip Plate (17)

Antibody Pair and Standard (1)

Publications

No (26)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (5)

Plasma (15)

Serum (15)

Tissue Homogenates (8)

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Rat SHH / Sonic Hedgehog (CLIA) ELISA Kit - LS-F39567

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Rat SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F21551

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F477

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

42 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Mouse SHH / Sonic Hedgehog (Custom ELISA) ELISA Kit - LS-F18616

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Rat SHH / Sonic Hedgehog (Custom ELISA) ELISA Kit - LS-F18617

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Human SHH / Sonic Hedgehog (Custom ELISA) ELISA Kit - LS-F18618

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$585

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Chicken SHH / Sonic Hedgehog (Custom ELISA) ELISA Kit - LS-F18619

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F5010

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78.13 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Rat SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F7213

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$750

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Porcine SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F44806

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Monkey SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F44805

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Rabbit SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F44808

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

3.125 - 200 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Human SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F35003

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F35005

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F35822

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F23983

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Mouse SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F23072

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Mouse SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F27624

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

10 - 250 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Rat SHH / Sonic Hedgehog (Competitive EIA) ELISA Kit - LS-F28076

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Mouse SHH / Sonic Hedgehog (CLIA) ELISA Kit - LS-F30745

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

7.813 - 500 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Human SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F27223

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Human SHH / Sonic Hedgehog (CLIA) ELISA Kit - LS-F29645

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Human SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F52649

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$968

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Human SHH / Sonic Hedgehog (Sandwich ELISA) ELISA Kit - LS-F74571

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$678

Select

DevKit DuoPlus Rat SHH / Sonic Hedgehog ELISA Development Kit - LS-F72158

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Rat

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,305; 1000 Wells/$1,952

Viewing 1-25 of 26 product results

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