RET

ret proto-oncogene

Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.

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Products

ELISA Kits (10)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Competitive EIA (2)

Custom (3)

Sandwich (2)

Target

RET (10)

Reactivity

Human (6)

Mouse (5)

Rat (4)

Format

96-Well Microplate (3)

96-Well Strip Plate (6)

Publications

No (10)

Sample Type

Adherent Cell Cultures (3)

Cell Culture Supernatants (2)

Cell Lysates (1)

Heparin Plasma (1)

Plasma (3)

Serum (4)

Tissue Homogenates (2)

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Mouse/Human/Rat Phospho-RET (Tyr1062) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1615

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse RET (Competitive EIA) ELISA Kit - LS-F38875

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

246.9 - 20000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$910

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Human RET (Sandwich ELISA) ELISA Kit - LS-F35560

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human RET (Custom ELISA) ELISA Kit - LS-F17778

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Rat RET (Custom ELISA) ELISA Kit - LS-F17779

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse RET (Custom ELISA) ELISA Kit - LS-F17780

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse/Human/Rat RET (Cell-Based ELISA) ELISA Kit - LS-F2285

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Human RET (Sandwich ELISA) ELISA Kit - LS-F57450

Type:

Sandwich

Reactivity:

Human

Range:

93.8 - 6000 pg/ml

Sample Types:

Cell Culture Supernatants, Heparin Plasma, Serum

Price:

1 Plate/$795

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RET (Competitive EIA) ELISA Kit - LS-F6126

Type:

Competitive EIA

Format:

96-Well Strip Plate

Range:

123.46 - 10000 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$946

Select

Mouse/Human/Rat Phospho-RET (Tyr1015) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1218

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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