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NUMA1 / NUMA

nuclear mitotic apparatus protein 1

Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.

Gene Name: nuclear mitotic apparatus protein 1
Synonyms: NUMA1, Structural nuclear protein, NuMA protein, SP-H antigen, NUMA
Target Sequences: NM_006185 NP_006176.2 Q14980

Publications (3)

1
Spectrum of Posttransplant Lymphoproliferations in NSG Mice and Their Association With EBV Infection After Engraftment of Pediatric Solid Tumors. Heather Tillman, Peter Vogel, Tiffani Rogers, Walter Akers, Jerold E Rehg. Veterinary pathology. 2020 May;57:445-456. [Full Text Article] [PubMed:32202225] [PMC:PMC7478125] Related Antibodies: LS-B11047.
2
Morphologic and Immunohistochemical Characterization of Spontaneous Lymphoma/Leukemia in NSG Mice. Heather Tillman, Laura J Janke, Amy Funk, Peter Vogel, Jerold E Rehg. Veterinary pathology. 2020 January;57:160-171. [Full Text Article] [PubMed:31736441] [PMC:PMC8686194] Related Antibodies: LS-B11047.
3
Development of Mast Cell and Eosinophil Hyperplasia and HLH/MAS-Like Disease in NSG-SGM3 Mice Receiving Human CD34+ Hematopoietic Stem Cells or Patient-Derived Leukemia Xenografts. Laura J Janke, Denise M Imai, Heather Tillman, Rosalinda Doty, Mark J Hoenerhoff, Jiajie J Xu, Zachary T Freeman, Portia Allen, Natalie Wall Fowlkes, Ilaria Iacobucci, Kirsten Dickerson, Charles G Mullighan, Peter Vogel, Jerold E Rehg. Veterinary pathology. 2021 January;58:181-204. [Full Text Article] [PubMed:33208054] [PMC:PMC8414369] Related Antibodies: LS-B11047.

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Products
Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
NUMA1 / NUMA (4)
No (4)
6His, N-terminus (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
NUMA1 / NUMA Protein - Recombinant  Nuclear Mitotic Apparatus Protein 1 By SDS-PAGE
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E. coli
6His, N-terminus
48.7 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
NUMA1 / NUMA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
130.49 kDa
20 µg/$215
NUMA1 / NUMA Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NUMA1 / NUMA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
130.49 kDa
100 µg/$710
Viewing 1-4 of 4 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).