NPC2

Niemann-Pick disease, type C2

Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.

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Products

Antibodies (40)

Type

Primary (40)

Target

NPC2 (40)

Reactivity

Human (34)

Mouse (7)

Rat (5)

Dog (4)

Monkey (1)

Application

IHC (9)

IHC-P (7)

WB (24)

ELISA (21)

ICC (1)

IF (3)

IP (2)

Peptide-ELISA (3)

Host

rabbit (35)

mouse (3)

goat (2)

Isotype

IgG (18)

IgG1 (2)

IgG2b,k (1)

Clonality

monoclonal mc (6)

polyclonal pc (34)

Clone

012 (1)

02 (1)

031 (1)

034 (1)

09 (1)

1F4 (1)

Format

APC (1)

APC Conjugated (1)

Biotin Conjugated (3)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Preservative Free (5)

Unconjugated (27)

Epitope

aa20-151 (8)

aa22-149 (4)

aa18-30 (1)

aa18-31 (1)

Publications

No (40)

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NPC2 Antibody (clone 012, Preservative Free) LS-C819111

Antibody:

NPC2 Rabbit anti-Human Monoclonal (Preservative Free) (012) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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NPC2 Antibody (clone 034, Preservative Free) LS-C819107

Antibody:

NPC2 Rabbit anti-Human Monoclonal (Preservative Free) (034) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

20 µl/$271; 100 µl/$412

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NPC2 Antibody (clone 031, Preservative Free) LS-C819110

Antibody:

NPC2 Rabbit anti-Human Monoclonal (Preservative Free) (031) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

20 µl/$271; 100 µl/$412

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NPC2 Antibody (Biotin) LS-C376231

Antibody:

NPC2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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NPC2 Antibody (aa20-151, PE) LS-C728466

Antibody:

NPC2 Rabbit anti-Human Polyclonal (aa20-151) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084; 2 ml/$1,441; 5 ml/$2,703

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NPC2 Antibody LS-C334047

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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NPC2 Antibody LS-C482439

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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NPC2 Antibody LS-C488506

Antibody:

NPC2 Rabbit anti-Rat Polyclonal Antibody

Reactivity:

Rat

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$412

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NPC2 Antibody LS-C662939

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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NPC2 Antibody LS-C488474

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

Select

NPC2 Antibody LS-C155292

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

Select

NPC2 Antibody LS-C806642

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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NPC2 Antibody LS-C341613

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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NPC2 Antibody LS-C832175

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

NPC2 Antibody LS-C830669

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

NPC2 Antibody LS-C488503

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

Select

NPC2 Antibody LS-C667231

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

NPC2 Antibody LS-C782126

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

Select

NPC2 Antibody (clone 1F4) LS-C139240

Antibody:

NPC2 Mouse anti-Human Monoclonal (1F4) Antibody

Reactivity:

Human

Applications:

ELISA, IP

Format:

Unconjugated

Price:

100 µg/$423

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NPC2 Antibody (aa18-30) LS-C139762

Antibody:

NPC2 Goat anti-Mouse Polyclonal (aa18-30) Antibody

Reactivity:

Mouse, Rat

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

NPC2 Antibody (aa22-149) LS-C371442

Antibody:

NPC2 Rabbit anti-Dog Polyclonal (aa22-149) Antibody

Reactivity:

Dog

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

NPC2 Antibody (aa18-31) LS-C112961

Antibody:

NPC2 Goat anti-Human Polyclonal (aa18-31) Antibody

Reactivity:

Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

NPC2 Antibody (clone 02, Preservative Free) LS-C820117

Antibody:

NPC2 Mouse anti-Human Monoclonal (Preservative Free) (02) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

Select

NPC2 Antibody LS-C488473

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

Select

NPC2 Antibody LS-C488501

Antibody:

NPC2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

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