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MMP13

matrix metallopeptidase 13 (collagenase 3)

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

Gene Name: matrix metallopeptidase 13 (collagenase 3)
Family/Subfamily: Protease , Metallopeptidase M10A
Synonyms: MMP13, Collagenase 3, Matrix metalloproteinase-13, Interstitial collagenase, MANDP1, MMP-13, CLG3
Target Sequences: NM_002427 NP_002418.1 P45452

Publications (6)

1
Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep. Cake MA, Read RA, Corfield G, Daniel A, Burkhardt D, Smith MM, Little CB. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2013 21:226-36. (IHC; Sheep) [PubMed:23069853]
2
The role of inhibition by phosphocitrate and its analogue in chondrocyte differentiation and subchondral bone advance in Hartley guinea pigs. Sun Y, Kiraly AJ, Cox M, Mauerhan DR, Hanley EN Jr. Experimental and therapeutic medicine. 2018 April;15:3320-3328. (Rat) [Full Text Article] [PubMed:29545850] [PMC:PMC5841021]
3
Short-Term Intake of a Fructose-, Fat- and Cholesterol-Rich Diet Causes Hepatic Steatosis in Mice: Effect of Antibiotic Treatment. Brandt A, Jin CJ, Nolte K, Sellmann C, Engstler AJ, Bergheim I. Nutrients. 2017 September;9:pii: E1013. (Rat) [Full Text Article] [PubMed:28906444] [PMC:PMC5622773]
4
Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection. Zhang Y, Wei X, Browning S, Scuderi G, Hanna LS, Wei L. Arthritis research & therapy. 2017 July;19:175. [Full Text Article] [PubMed:28743292] [PMC:PMC5526282]
5
Aspirin-triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E-/-<sup> mice. Petri MH, Laguna-Fernandez A, Arnardottir H, Wheelock CE, Perretti M, Hansson GK, Bäck M. British journal of pharmacology. 2017 November;174:4043-4054. [Full Text Article] [PubMed:28071789] [PMC:PMC5659998]
6
Atelocollagen promotes chondrogenic differentiation of human adipose-derived mesenchymal stem cells. Seon Ae Kim, Yoo Joon Sur, Mi-La Cho, Eun Jeong Go, Yun Hwan Kim, Asode Ananthram Shetty, Seok Jung Kim. Scientific reports. 2020 June;10:10678. [Full Text Article] [PubMed:32606308] [PMC:PMC7327030]
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Products
ELISA Kits (46)
Cell-Based (1)
Competitive EIA (2)
Custom (1)
Sandwich (31)
Sandwich CLIA (11)
MMP13 (46)
Human (12)
Mouse (8)
Rat (7)
Bovine (2)
Chicken (3)
Guinea pig (1)
Horse (2)
Monkey (1)
Pig (2)
Porcine (1)
Rabbit (5)
Sheep (1)
12 x 8-Well Microstrips (3)
96-Well Microplate (7)
96-Well Strip Plate (36)
No (43)
Yes (3)
Adherent Cell Cultures (1)
Cell Culture Supernatants (7)
Cell Lysates (5)
Cell Supernatant (1)
Plasma (41)
Serum (41)
Tissue Homogenates (13)
MMP13 ELISA Kit
Select
Sandwich
96-Well Microplate
Rabbit
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
MMP13 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
54.9 - 40000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$851
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
MMP13 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MMP13 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$582
MMP13 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
8.23 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$779
MMP13 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
27.4 - 20000 pg/ml
Chemiluminescent
Plasma, Serum, Tissue Homogenates
1 Plate/$871
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
MMP13 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MMP13 ELISA Kit
Select
Sandwich
96-Well Microplate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MMP13 ELISA Kit
Select
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
MMP13 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
MMP13 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$779
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).