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Unfortunately, the antibody LS-C139696 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



MALIN / NHLRC1 Antibodies

NHL repeat containing E3 ubiquitin protein ligase 1

Gene Name: NHL repeat containing E3 ubiquitin protein ligase 1
Synonyms: NHLRC1 Antibody, BA204B7.2 Antibody, EPM2B Antibody, MALIN Antibody, NHL repeat containing 1 Antibody
Target Sequences: NP_940988.2 Q6VVB1
 MALIN / NHLRC1 Feature Table

MALIN / NHLRC1 Antibodies (18)

Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 Atto 680 Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, Atto 680) LS-C230091
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
Atto 680 Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 Atto 700 Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, Atto 700) LS-C230093
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
Atto 700 Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 Atto 633 Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, Atto 633) LS-C230089
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
Atto 633 Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 Atto 655 Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, Atto 655) LS-C230090
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
Atto 655 Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 AP Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, AP) LS-C230094
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
AP Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 HRP Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, HRP) LS-C230098
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
HRP Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 FITC Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, FITC) LS-C230099
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
FITC Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 APC Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, APC) LS-C230096
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
APC Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 Biotin Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, Biotin) LS-C230097
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
Biotin Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 Atto 488 Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, Atto 488) LS-C229155
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
Atto 488 Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 Atto 565 Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, Atto 565) LS-C229156
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
Atto 565 Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 Unconjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18) LS-C209535
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
Unconjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 Atto 390 Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, Atto 390) LS-C229153
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
Atto 390 Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 Atto 594 Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, Atto 594) LS-C229157
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
Atto 594 Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 PerCP Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, PerCP) LS-C229160
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
PerCP Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 SA Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, SA) LS-C229161
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
SA Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 PE-Atto 594 Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, PE-Atto 594) LS-C229158
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
PE-Atto 594 Conjugated
MALIN / NHLRC1 Mouse IgG1 Monoclonal S85-18 RPE Conjugated Human ICC, WB aa2-125 No Primary
Anti-MALIN / NHLRC1 Antibody (aa2-125, clone S85-18, RPE) LS-C229159
Mouse Monoclonal [clone S85-18] (IgG1) to Human MALIN / NHLRC1
Human
ICC, Western blot
RPE Conjugated

MALIN / NHLRC1 Feature Table


Feature Type Location Details
Disease 1 - 395 Defects in NHLRC1 are a cause of progressive myoclonic epilepsy type 2 (EPM2) [MIM:254780]; also known as Lafora disease. EPM2 is an autosomal recessive and severe form of adolescent-onset progressive epilepsy. Typically, as seizures increase in frequency, cognitive function declines towards dementia, and affected individuals die usually within 10 years after onset. EPM2 occurs worldwide, but it is particularly common in the mediterranean countries of southern Europe and northern Africa, in southern India and in the Middle East. At the cellular level, it is characterized by accumulation of starch-like polyglucosans called Lafora bodies (LBs) that are most abundant in organs with the highest glucose metabolism: brain, heart, liver and skeletal muscle. Among other conditions involving polyglucosans, EPM2 is unique in that the inclusions are in neuronal dendrites but not axons and
domain 1 - 395 The RING domain is essential for ubiquitin E3 ligase activity.
Function 1 - 395 E3 ubiquitin-protein ligase which in complex with EPM2A/laforin and HSP70 suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates PPP1R3C/PTG in a laforin-dependent manner, and targets it for proteasome-dependent degradation and this degradation decreases glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation.
pathway 1 - 395 Protein modification; protein ubiquitination.
Similarity 1 - 395 Contains 1 RING-type zinc finger.
Similarity 1 - 395 Contains 6 NHL repeats.
Subcellular Location 1 - 395 Endoplasmic reticulum. Nucleus. Note=Localizes at the endoplasmic reticulum and, to a lesser extent, in the nucleus.
Subunit 1 - 395 Interacts with AGL. Interacts (via the NHL repeats) with EPM2A/laforin. Forms a complex with EPM2A/laforin and HSP70.
Tissue Specificity 1 - 395 Expressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle and pancreas.
web resource 1 - 395 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NHLRC1";
web resource 1 - 395 Name=The Lafora progressive myoclonus epilepsy mutation and polymorphism database; URL="http://projects.tcag.ca/lafora/";
arrayexpress 1 - 395 Q6VVB1
cleanex 1 - 395 HS_NHLRC1
ctd 1 - 395 378884
doi 1 - 395 10
eggnog 1 - 395 prNOG18504
embl 1 - 395 AL589723
embl 1 - 395 AY324850
embl 1 - 395 BC103888
embl 1 - 395 BC103889
embl 1 - 395 BC103890
embl 1 - 395 BK001510
ensembl 1 - 395 ENST00000340650
gene3d 1 - 395 G3DSA:2.120.10.30
genecards 1 - 395 GC06M018120
geneid 1 - 395 378884
genevestigator 1 - 395 Q6VVB1
go 1 - 395 GO:0000209
go 1 - 395 GO:0004842
go 1 - 395 GO:0005515
go 1 - 395 GO:0005634
go 1 - 395 GO:0005783
go 1 - 395 GO:0008270
go 1 - 395 GO:0043161
h-invdb 1 - 395 HIX0032861
hgnc 1 - 395 HGNC:21576
hogenom 1 - 395 HBG716014
hovergen 1 - 395 HBG052617
inparanoid 1 - 395 Q6VVB1
interpro 1 - 395 IPR001841
interpro 1 - 395 IPR011042
interpro 1 - 395 IPR013017
interpro 1 - 395 IPR017907
ipi 1 - 395 IPI00440247
kegg 1 - 395 hsa:378884
medline 1 - 395 22879922
medline 1 - 395 22935763
mim 1 - 395 254780
mim 1 - 395 608072
nextbio 1 - 395 100856
oma 1 - 395 NLPCGHV
orphanet 1 - 395 501
orthodb 1 - 395 EOG93JFQG
pharmgkb 1 - 395 PA134916338
phylomedb 1 - 395 Q6VVB1
pride 1 - 395 Q6VVB1
prosite 1 - 395 PS00518
prosite 1 - 395 PS50089
prosite 1 - 395 PS51125
proteinmodelportal 1 - 395 Q6VVB1
pubmed 1 - 395 12958597
pubmed 1 - 395 14574404
pubmed 1 - 395 15489334
pubmed 1 - 395 15781812
pubmed 1 - 395 15930137
pubmed 1 - 395 16021330
pubmed 1 - 395 17908927
pubmed 1 - 395 18070875
pubmed 1 - 395 18311786
pubmed 1 - 395 19036738
refseq 1 - 395 NP_940988.2
smart 1 - 395 SM00184
smr 1 - 395 Q6VVB1
string 1 - 395 Q6VVB1
ucsc 1 - 395 uc003ncl.1
unigene 1 - 395 Hs.348351
chain 1 - 395 E3 ubiquitin-protein ligase NHLRC1 /FTId=PRO_0000055980.
mutagen 280 - 280 E->K: Loss of interaction with EP2MA
repeat 113 - 157 NHL 1
repeat 161 - 204 NHL 2
repeat 205 - 245 NHL 3
repeat 248 - 300 NHL 4
repeat 301 - 349 NHL 5
repeat 350 - 393 NHL 6
variant 22 - 22 S -> R (in EPM2; does not significantly alters the subcellular location as compared to the wild-type). /FTId=VAR_046387.
variant 26 - 26 C -> S (in EPM2; dbSNP:rs28940575) /FTId=VAR_019482.
variant 33 - 33 F -> S (in EPM2) /FTId=VAR_019483.
variant 67 - 67 E -> Q (in EPM2) /FTId=VAR_046388.
variant 68 - 68 C -> Y (in EPM2) /FTId=VAR_046389.
variant 69 - 69 P -> A (in EPM2; dbSNP:rs28940576) /FTId=VAR_019484.
variant 87 - 87 L -> P (in EPM2) /FTId=VAR_019485.
variant 111 - 111 P -> L (common polymorphism; dbSNP:rs10949483). /FTId=VAR_019486.
variant 126 - 126 L -> P (in EPM2; the mutant protein targeted exclusively nucleus as compared to predominantly cytoplasmic and partially nuclear localization of the wild-type protein). /FTId=VAR_046390.
variant 146 - 146 D -> N (in EPM2) /FTId=VAR_019487.
variant 153 - 153 I -> M (in EPM2) /FTId=VAR_046391.
variant 160 - 160 C -> R (in EPM2) /FTId=VAR_046392.
variant 198 - 198 I -> N (in EPM2) /FTId=VAR_046393.
variant 219 - 219 W -> R (in EPM2) /FTId=VAR_046394.
variant 233 - 233 D -> A (in EPM2) /FTId=VAR_046395.
variant 245 - 245 D -> N (in EPM2) /FTId=VAR_046396.
variant 253 - 253 R -> K (in EPM2) /FTId=VAR_046397.
variant 264 - 264 P -> H (in EPM2) /FTId=VAR_046398.
variant 279 - 279 L -> P (in EPM2; significantly alters the distribution of the protein; a great majority of cells expressing the mutant form formed perinuclear inclusion when compared with the wild-type form). /FTId=VAR_046399.
variant 294 - 295 Missing (in EPM2) /FTId=VAR_046400.
variant 302 - 302 Q -> P (in EPM2; loss of interaction with EPM2A). /FTId=VAR_019488.
variant 308 - 308 D -> A (in EPM2) /FTId=VAR_046401.
zn_fing 26 - 72 RING-type
keyword 1 - 395 Complete proteome
keyword 1 - 395 Disease mutation
keyword 1 - 395 Endoplasmic reticulum
keyword 1 - 395 Epilepsy
keyword 1 - 395 Ligase
keyword 1 - 395 Metal-binding
keyword 1 - 395 Nucleus
keyword 1 - 395 Polymorphism
keyword 1 - 395 Repeat
keyword 1 - 395 Ubl conjugation pathway
keyword 1 - 395 Zinc
keyword 1 - 395 Zinc-finger
Molecular Weight 1 - 395 42293
1 hit 1 - 395 PS00518
1 hit 1 - 395 PS50089
6 hits 1 - 395 PS51125

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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