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KRT5 / CK5 / Cytokeratin 5

keratin 5

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Gene Name: keratin 5
Family/Subfamily: Keratin , not assigned-Keratin
Synonyms: KRT5, 58 kd cytokeratin, 58 kDa cytokeratin, CK5, CK-5, Cytokeratin-5, DDD, EBS2, Keratin 5, KRT5A, Type-II keratin Kb5, Cytokeratin 5, K5, Keratin-5
Target Sequences: NM_000424 NP_000415.2 P13647

Publications (6)

1
A case of primary combined neuroendocrine carcinoma with squamous cell carcinoma in the upper gingiva. Mochizuki Y, Omura K, Sakamoto K, Nakanishi S, Satoh K, Marukawa E, Yamaguchi A. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2010 109:e34-9. (IHC) [PubMed:20303044]
2
Aldosterone and angiotensin II induce protein aggregation in renal proximal tubules. Cheema MU, Poulsen ET, Enghild JJ, Hoorn EJ, Fenton RA, Praetorius J. Physiological reports. 2013 1:e00064. (WB; Human) [Full Text Article] [PubMed:24303148] [PMC:PMC3831891] Related Antibodies: LS-B5496.
3
Intravesical Administration of Xenogeneic Porcine Urothelial Cells Attenuates Cyclophosphamide-Induced Cystitis in Mice. Huang CP, Chen CC, Tsai YT, Wu CC, Shyr CR. Cell transplantation. 2019 March;28:296-305. [Full Text Article] [PubMed:30675801] [PMC:PMC6425110]
4
Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics. Ong JWJ, Tan KS, Ler SG, Gunaratne J, Choi H, Seet JE, Chow VT. Cells. 2019 August;8:E975. [Full Text Article] [PubMed:31455003] [PMC:PMC6769472] Related Antibodies: LS-C22715.
5
Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity. Drake Winslow Williams, Teresa Greenwell-Wild, Laurie Brenchley, Nicolas Dutzan, Andrew Overmiller, Andrew Phillip Sawaya, Simone Webb, Daniel Martin, NIDCD/NIDCR Genomics and Computational Biology Core ; George Hajishengallis, Kimon Divaris, Maria Morasso, Muzlifah Haniffa, Niki Maria Moutsopoulos. Cell. 2021 July;184:4090-4104.e15. [Full Text Article] [PubMed:34129837] [PMC:PMC8359928] Related Antibodies: LS-C22715.
6
FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers. Andrew P Sawaya, Rivka C Stone, Spencer Mehdizadeh, Irena Pastar, Stephen Worrell, Nathan C Balukoff, Mariana J Kaplan, Marjana Tomic-Canic, Maria I Morasso. EMBO reports. 2022 August;23:e54558. [Full Text Article] [PubMed:35856334] [PMC:PMC9346470] Related Antibodies: LS-C22715.
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Antibodies (106)
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KRT5 / CK5 / Cytokeratin 5 (106)
Human (88)
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aa163-471 (8)
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510-590 aa, C-terminal (1)
Amino Acid: 316-590 (1)
Synthetic peptide, corresponding to amino acids 550-600 of Human Cytokeratin 5. (1)
aa158-272 (1)
aa541-590 (1)
No (104)
Yes (2)
KRT5 / CK5 / Cytokeratin 5 Antibody - Anti-KRT5 / Cytokeratin 5 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Cancer Pathology
Cancer
KRT5 / CK5 / Cytokeratin 5 Rabbit anti-Human Polyclonal (aa541-590) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
KRT5 / CK5 / Cytokeratin 5 Antibody - Anti-KRT5 / CK5 / Cytokeratin 5 antibody IHC staining of human skin, epidermis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer Pathology
Cancer
KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (aa158-272) (2C2) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
KRT5 / CK5 / Cytokeratin 5 Antibody - Anti-KRT5 / Cytokeratin 5 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (3E2F1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$485
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KRT5 / CK5 / Cytokeratin 5 Guinea pig anti-Human Polyclonal Antibody
Mouse, Bovine, Human
IHC-Fr, IHC-P, WB
Unconjugated
100 µl/$1,017
KRT5 / CK5 / Cytokeratin 5 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
KRT5 / CK5 / Cytokeratin 5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
KRT5 / CK5 / Cytokeratin 5 Antibody - Anti-KRT5 / Cytokeratin 5 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (10) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
KRT5 / CK5 / Cytokeratin 5 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded Human Lung squamous cell carcinoma (A), normal hepatocyte (B), colon adenocacinoma (C), normal stomach tissue (D), showing cytoplasmic and membrane localization with DAB staining using Cytokeratin (Pan) M.
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KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
KRT5 / CK5 / Cytokeratin 5 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (aa316-590) (2C2B4) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$440
KRT5 / CK5 / Cytokeratin 5 Antibody - Cytokeratin 5 Antibody in Immunohistochemistry (IHC)
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KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (2C2) Antibody
Mouse, Human, Non-Human Primate
Flo, ICC, IF, IHC, WB
Unconjugated
100 µg/$503
KRT5 / CK5 / Cytokeratin 5 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (OTI1C7) Antibody
Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
KRT5 / CK5 / Cytokeratin 5 Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
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KRT5 / CK5 / Cytokeratin 5 Rabbit anti-Human Polyclonal (Synthetic peptide, corresponding to amino acids 550-600 of Human Cytokeratin 5.) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
KRT5 / CK5 / Cytokeratin 5 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (4H8) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
KRT5 / CK5 / Cytokeratin 5 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
KRT5 / CK5 / Cytokeratin 5 Rabbit anti-Human Polyclonal (510-590 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$460
KRT5 / CK5 / Cytokeratin 5 Antibody - Western Blot analysis of KRT5 expression in transfected 293T cell line by KRT5 monoclonal antibody (M08), clone 1A12.Lane 1: KRT5 transfected lysate(62.4 KDa).Lane 2: Non-transfected lysate.
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KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (1A12) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
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KRT5 / CK5 / Cytokeratin 5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$332
KRT5 / CK5 / Cytokeratin 5 Antibody - IHC of paraffin-embedded prostate tissues using CK5 mouse monoclonal antibody with DAB staining.
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KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (aa316-590) (10C11E6) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
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KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (2C8E4) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
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KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (3D6D4) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
KRT5 / CK5 / Cytokeratin 5 Antibody - ICC/IF analysis of KRT5 in A549 cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human KRT5 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
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KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (AT12C4) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
50 µl/$303; 100 µl/$365
KRT5 / CK5 / Cytokeratin 5 Antibody - Western blot of recombinant KRT5 / CK5 / Cytokeratin 5.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KRT5 / CK5 / Cytokeratin 5 Rabbit anti-Human Polyclonal (aa166-474) (Biotin) Antibody
Mouse, Rat, Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558
KRT5 / CK5 / Cytokeratin 5 Antibody - Western blot of recombinant KRT5 / CK5 / Cytokeratin 5.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KRT5 / CK5 / Cytokeratin 5 Rabbit anti-Mouse Polyclonal (aa163-471) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$338; 200 µl/$392; 500 µl/$573; 1 ml/$698; 2 ml/$936; 5 ml/$1,588
KRT5 / CK5 / Cytokeratin 5 Antibody - Western blot of recombinant KRT5 / CK5 / Cytokeratin 5.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KRT5 / CK5 / Cytokeratin 5 Rabbit anti-Mouse Polyclonal (aa163-471) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$392; 200 µl/$470; 500 µl/$798; 1 ml/$951; 2 ml/$1,211; 5 ml/$2,269
KRT5 / CK5 / Cytokeratin 5 Antibody - 1:100 staining human colon carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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KRT5 / CK5 / Cytokeratin 5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
KRT5 / CK5 / Cytokeratin 5 Antibody - IHC of paraffin-embedded bladder cancer tissues using CK5 mouse monoclonal antibody with DAB staining.
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KRT5 / CK5 / Cytokeratin 5 Mouse anti-Human Monoclonal (aa316-590) (10C11E6) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$459
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KRT5 / CK5 / Cytokeratin 5 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IP, WB
Unconjugated
100 µl/$412
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).