IRAK4 / IRAK-4

interleukin-1 receptor-associated kinase 4

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

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Products

Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

IRAK4 / IRAK-4 (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (1)

His (2)

Myc-DDK (Flag) (5)

Species

Human (7)

Source

293T Cells (2)

Baculovirus (1)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human IRAK4 / IRAK-4 Protein (Recombinant His) (aa189-427) - LS-G13949

Source:

E. coli

Tag:

His

Molecular Weight:

28.0 kDa

Price:

10 µg/$279; 50 µg/$425; 100 µg/$680; 200 µg/$850; 1 mg/$1,944; 500 µg/$1,490; 5 mg/$2,969; 2 mg/$2,131

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Human IRAK4 / IRAK-4 Protein (Recombinant GST) (Full Length) - LS-G33645

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

76.34 kDa

Price:

10 µg/$479; 25 µg/$670

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Human IRAK4 / IRAK-4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69558

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.3 kDa

Price:

20 µg/$1,107

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Human IRAK4 / IRAK-4 Protein (Recombinant GST, N-terminus) (aa1-130) - LS-G62408

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human IRAK4 / IRAK-4 Protein (Recombinant His) (Met1-Ser460) - LS-G97622

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

53.8 kDa

Price:

50 µg/$707; 500 µg/$4,129

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Human IRAK4 / IRAK-4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84940

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.3 kDa

Price:

20 µg/$150

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Human IRAK4 / IRAK-4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84939

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.3 kDa

Price:

20 µg/$150

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IRAK4 / IRAK-4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101388

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.3 kDa

Price:

100 µg/$494

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IRAK4 / IRAK-4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124346

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.3 kDa

Price:

100 µg/$494

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