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Infectious Disease
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IL2RA / CD25
interleukin 2 receptor, alpha
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
| Gene Name: | interleukin 2 receptor, alpha |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL2RA, CD25 antigen, CD25, IDDM10, IL-2 receptor subunit alpha, IL2R, Interleukin 2 receptor, alpha, IL-2-RA, IL2-RA, TCGFR, IL-2R subunit alpha, p55, TAC antigen |
| Target Sequences: | NM_000417 NP_000408.1 P01589 |
Publications (3)
1
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH. Journal of translational medicine. 2009 7:89.
[PubMed:19849846]
[PMC:PMC2770477]
Related Antibodies: LS-C40810.
2
A Myristoylated Alanine-Rich C Kinase Substrate-Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils. Li J, D'Annibale-Tolhurst MA, Adler KB, Fang S, Yin Q, Birkenheuer AJ, Levy MG, Jones SL, Sung EJ, Hawkins EC, Yoder JA, Nordone SK. American journal of respiratory cell and molecular biology. 2013 48:314-21.
[PubMed:23221047]
Related Antibodies: LS-C40810.
3
Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts. Coutinho de Souza P, Mallory S, Smith N, Saunders D, Li XN, McNall-Knapp RY, Fung KM, Towner RA. PloS one. 2015 10:e0134276. (WB, Flo; Human, Rat)
[Full Text Article]
[PubMed:26248280]
[PMC:PMC4527837]
☰ Filters
Products
Proteins
(27)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(23)
Target
IL2RA / CD25
(27)
Application
Bind
(1)
SDS-PAGE
(3)
Product Group
Coronavirus Antibodies Proteins cDNAs
(27)
Cytokine Release Syndrome
(27)
Cytokine Release Syndrome Proteins
(27)
Publications
No
(27)
Tag
6His, C-terminus
(2)
6His, N-terminus
(3)
8His, N-terminus
(1)
Fc, C-terminus
(3)
His
(2)
His, N-Terminal
(2)
His,C-terminus
(5)
His-S
(2)
His-T7
(3)
Human IgG1 Fc, C-terminus
(1)
Mouse IgG1 Fc
(1)
Myc-DDK (Flag)
(2)
Species
Bovine
(1)
Human
(14)
Mouse
(8)
Pig
(1)
Rat
(2)
Source
293T Cells
(1)
E. coli
(7)
HEK 293 Cells
(9)
Human Cells
(6)
Mammalian Cells
(4)
Purification
Purified
(4)
Low Endotoxin Level
Low endotoxin level
(15)
Biologically Active
Biologically active
(3)
Human Cells
Mouse IgG1 Fc
Less than 1.0 EU/µg protein (determined by LAL method).
55.5kD
10 µg/$281; 50 µg/$420; 500 µg/$1,585; 1 mg/$2,157
HEK 293 Cells
His, N-Terminal
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
42 kDa (SDS-PAGE)
50 µg/$355; 10 µg/$273; 1 mg/$1,656
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.5kD
10 µg/$277; 50 µg/$395; 500 µg/$1,262; 1 mg/$1,627
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22.8kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
E. coli
His, N-Terminal
37kDa
10 µg/$287; 50 µg/$482; 200 µg/$962; 100 µg/$770; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
E. coli
6His, N-terminus
24.5 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
E. coli
His-T7
25.6 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
HEK 293 Cells
His,C-terminus
Bind SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The mature recombinant human IL2Ra/Fc is a disulfide-linked homodimeric protein generated by proteolytic removal of the signal peptide. The reduced monomer consists of 430 amino acids and has a predicted molecular mass of 48.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhIL2Ra/Fc monomer is approximately 72 kDa due to glycosylation.
100 µg/$403; 1 mg/$1,697
HEK 293 Cells
His,C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human IL2Ra consists of 203 amino acids and has a predicted molecular mass of 23.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhIL2Ra is approximately 44 kDa due to glycosylation.
1 mg/$1,697; 100 µg/$403
E. coli
His-T7
29.0 kDa
10 µg/$290; 50 µg/$497; 100 µg/$795; 200 µg/$992; 1 mg/$2,134; 500 µg/$1,658; 5 mg/$3,473; 2 mg/$2,324
E. coli
His-T7
29.0 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
HEK 293 Cells
6His, N-terminus
22 kDa
200 µl/$283
HEK 293 Cells
6His, N-terminus
22 kDa
100 µg/$298
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant mouse IL2RA cmprises 226 amino acids with a predicted molecular mass of 26 kDa. As a result of glycosylation, the apparent molecular mass of the rm IL2RA is approximately 50-55 kDa in SDS-PAGE under reducing conditions.
100 µg/$441; 1 mg/$2,003
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
26 kDa
100 µg/$721
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
23.3 kDa
100 µg/$839; 1 mg/$4,452
HEK 293 Cells
Human IgG1 Fc, C-terminus
Less than 0.2 EU/µg protein (determined by LAL method).
65-75 kDa
10 µg/$313; 50 µg/$508
HEK 293 Cells
8His, N-terminus
40 kDa
10 µg/$289; 50 µg/$360; 100 µg/$432; 500 µg/$1,270
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.9kD
10 µg/$277; 50 µg/$395; 500 µg/$1,203; 1 mg/$1,627
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.5 kDa
10 µg/$277; 50 µg/$389
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.9 kDa
10 µg/$277; 50 µg/$389
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
55.5 kDa
10 µg/$281; 50 µg/$414
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
22.8 kDa
10 µg/$288; 50 µg/$436
E. coli
His-S
30.0 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
E. coli
His-S
30.3 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
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product results
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