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IL15

interleukin 15

IL15 is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.

Gene Name: interleukin 15
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: IL15, Interleukin-15, IL-15, Interleukin 15
Target Sequences: NM_000585 NP_000576.1 P40933

Publications (1)

1
Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression. Ralph Francescone , Débora Barbosa Vendramini-Costa , Janusz Franco-Barraza, Jessica Wagner, Alexander Muir, Allison N Lau, Linara Gabitova, Tatiana Pazina, Sapna Gupta, Tiffany Luong, Dustin Rollins, Ruchi Malik, Roshan J Thapa, Diana Restifo, Yan Zhou, Kathy Q Cai, Harvey H Hensley, Yinfei Tan, Warren D Kruger, Karthik Devarajan, Siddharth Balachandran, Andres J Klein-Szanto, Huamin Wang, Wafik S El-Deiry, Matthew G Vander Heiden, Suraj Peri, Kerry S Campbell, Igor Astsaturov, Edna Cukierman. Cancer discovery. 2021 February;11:446-479. [Full Text Article] [PubMed:33127842] [PMC:PMC7858242] Related Antibodies: LS-B10080.

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Antibodies (110)
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IL15 (110)
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IL15 Antibody - Anti-IL15 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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IL15 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
IL15 Antibody - Western Blot (non-reducing) of IL-15 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL15 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
IL15 Antibody - Western Blot (non-reducing) of IL-15 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL15 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
IL15 Antibody - Western Blot (non-reducing) of IL-15 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL15 Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
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IL15 Rabbit anti-Human Polyclonal (aa49-162) Antibody
Human
ELISA
Unconjugated
20 µl/$286; 100 µl/$435
IL15 Antibody - IL15 / IL-15 antibody Western blot of 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL15 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
IL15 Antibody - IL15 / IL-15 antibody Western blot of 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL15 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Mouse, Guinea pig, Sheep, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
HRP Conjugated
100 µl/$469
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IL15 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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IL15 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, Neut, WB
Unconjugated
100 µg/$829
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IL15 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IP, Neut, WB
HRP Conjugated
100 µl/$1,036
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IL15 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IP, Neut, WB
Biotin Conjugated
100 µl/$1,036
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IL15 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IP, Neut, WB
FITC Conjugated
100 µl/$1,036
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IL15 Rabbit anti-Human Polyclonal (PE) Antibody
Human
ELISA, IP, Neut, WB
PE Conjugated
100 µl/$1,036
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IL15 Rabbit anti-Human Monoclonal (111) Antibody
Human
ELISA
Unconjugated
20 µl/$271; 100 µl/$412
IL15 Antibody - Western blot analysis of IL-15 expression in HepG2 (A), HEK293T (B), AML12 (C), H9C2 (D) whole cell lysates.
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IL15 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
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IL15 Rabbit anti-Human Monoclonal (Preservative Free) (112) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
IL15 Antibody - Western blot of recombinant IL15.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL15 Rabbit anti-Human Polyclonal (aa50-162) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$395; 200 µl/$475; 500 µl/$811; 1 ml/$965; 2 ml/$1,233; 5 ml/$2,311
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IL15 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
IL15 Antibody - 1:100 staining mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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IL15 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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IL15 Mouse anti-Human Monoclonal (2F6) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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IL15 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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IL15 Mouse anti-Human Monoclonal (Preservative Free) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
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IL15 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IL15 Antibody - IL15 antibody Western blot. All lanes: Anti IL15 at 0.5 ug/ml. WB: Recombinant Human IL15 Protein 0.5ng. Predicted band size: 15 kD. Observed band size: 15 kD.
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IL15 Rabbit anti-Human Polyclonal (aa49-162) Antibody
Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
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IL15 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P
Unconjugated
100 µg/$357
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).