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HBB / Hemoglobin Beta

hemoglobin, beta

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin that sickles causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Gene Name: hemoglobin, beta
Synonyms: HBB, CD113t-C, Hemoglobin beta, Hemoglobin beta chain, Hemoglobin subunit beta, Beta globin chain, Beta-globin, Hemoglobin, beta
Target Sequences: NM_000518 NP_000509.1 P68871

Publications (1)

1
Iron imaging in myocardial infarction reperfusion injury. Brianna F Moon, Srikant Kamesh Iyer, Eileen Hwuang, Michael P Solomon, Anya T Hall, Rishabh Kumar, Nicholas J Josselyn, Elizabeth M Higbee-Dempsey, Andrew Tsourkas, Akito Imai, Keitaro Okamoto, Yoshiaki Saito, James J Pilla, Joseph H Gorman rd, Robert C Gorman, Cory Tschabrunn, Samuel J Keeney, Estibaliz Castillero, Giovanni Ferrari, Steffen Jockusch, Felix W Wehrli, Haochang Shou, Victor A Ferrari, Yuchi Han, Avanti Gulhane, Harold Litt, William Matthai, Walter R Witschey. Nature communications. 2020 June;11:3273. [Full Text Article] [PubMed:32601301] [PMC:PMC7324567] Related Antibodies: LS-C755633.

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Products
Antibodies (72)
Primary (72)
HBB / Hemoglobin Beta (72)
Human (22)
Mouse (17)
Rat (10)
Bovine (16)
Chicken (10)
Cow (8)
Horse (8)
Monkey (1)
Porcine (1)
Sheep (15)
IHC (9)
IHC-Fr (1)
IHC-P (8)
WB (69)
ELISA (11)
ICC (2)
IP (1)
Peptide-ELISA (1)
rabbit (57)
mouse (15)
Product Group
IHCPlus (4)
IgG (17)
IgG1 (2)
IgG1,k (2)
IgG2a,l (2)
monoclonal mc (15)
polyclonal pc (57)
14G2.G11.F11 (2)
7B12 (1)
PLA114 (1)
APC (7)
APC Conjugated (7)
Biotin Conjugated (8)
Cy3 Conjugated (7)
Cy7 Conjugated (7)
FITC Conjugated (9)
HRP Conjugated (8)
PE Conjugated (7)
Unconjugated (19)
aa1-147 (39)
aa1-145 (23)
N-Terminus (2)
No (71)
Yes (1)
HBB / Hemoglobin Beta Antibody - Anti-HBB antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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HBB / Hemoglobin Beta Mouse anti-Human Monoclonal (7B12) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
HBB / Hemoglobin Beta Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HBB / Hemoglobin Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HBB / Hemoglobin Beta Antibody
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HBB / Hemoglobin Beta Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$445
HBB / Hemoglobin Beta Antibody - Western blot of recombinant HBB / Hemoglobin Beta.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBB / Hemoglobin Beta Rabbit anti-Chicken Polyclonal (aa1-147) Antibody
Chicken
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
HBB / Hemoglobin Beta Antibody - Western blot of recombinant HBB / Hemoglobin Beta.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBB / Hemoglobin Beta Rabbit anti-Chicken Polyclonal (aa1-147) (Biotin) Antibody
Chicken
WB
Biotin Conjugated
100 µl/$328; 200 µl/$378; 500 µl/$545; 1 ml/$645; 2 ml/$879; 5 ml/$1,464
HBB / Hemoglobin Beta Antibody - Clone PLA-114 swine ileum, frozen section
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HBB / Hemoglobin Beta Mouse anti-Porcine Monoclonal (PLA114) Antibody
Porcine
IHC, IHC-Fr, IHC-P, WB
Unconjugated
200 µg/$703
HBB / Hemoglobin Beta Antibody
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HBB / Hemoglobin Beta Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$445
HBB / Hemoglobin Beta Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HBB / Hemoglobin Beta Rabbit anti-Human Polyclonal (aa1-147) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
HBB / Hemoglobin Beta Antibody - Western blot of recombinant HBB / Hemoglobin Beta.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBB / Hemoglobin Beta Rabbit anti-Mouse Polyclonal (aa1-147) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
HBB / Hemoglobin Beta Antibody - Western blot of recombinant HBB / Hemoglobin Beta.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBB / Hemoglobin Beta Rabbit anti-Mouse Polyclonal (aa1-147) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
HBB / Hemoglobin Beta Antibody - Western blot of HBB / Hemoglobin Beta antibody.
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HBB / Hemoglobin Beta Rabbit anti-Human Polyclonal (aa1-147) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
HBB / Hemoglobin Beta Antibody - Western blot of HBB / Hemoglobin Beta antibody.
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HBB / Hemoglobin Beta Rabbit anti-Human Polyclonal (aa1-147) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
HBB / Hemoglobin Beta Antibody - Western blot of HBB / Hemoglobin Beta antibody.
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HBB / Hemoglobin Beta Rabbit anti-Cow Polyclonal (aa1-145) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$328; 200 µl/$379; 500 µl/$547; 1 ml/$648; 2 ml/$883; 5 ml/$1,471
HBB / Hemoglobin Beta Antibody - Western blot of HBB / Hemoglobin Beta antibody.
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HBB / Hemoglobin Beta Rabbit anti-Cow Polyclonal (aa1-145) (FITC) Antibody
Bovine, Cow
WB
FITC Conjugated
100 µl/$375; 200 µl/$446; 500 µl/$725; 1 ml/$883; 2 ml/$1,135; 5 ml/$2,059
HBB / Hemoglobin Beta Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
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HBB / Hemoglobin Beta Rabbit anti-Human Polyclonal (aa1-147) Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
HBB / Hemoglobin Beta Antibody - Immunohistochemistry of paraffin-embedded human liver using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBB / Hemoglobin Beta Rabbit anti-Human Polyclonal (aa1-147) (HRP) Antibody
Human
ELISA, IHC, IHC-P
HRP Conjugated
50 µg/$294; 100 µg/$360
HBB / Hemoglobin Beta Antibody - Immunohistochemistry of paraffin-embedded human liver using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBB / Hemoglobin Beta Rabbit anti-Human Polyclonal (aa1-147) (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
HBB / Hemoglobin Beta Antibody - Immunohistochemistry of paraffin-embedded human liver using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBB / Hemoglobin Beta Rabbit anti-Human Polyclonal (aa1-147) (FITC) Antibody
Human
ELISA, IHC, IHC-P
FITC Conjugated
50 µg/$294; 100 µg/$360
HBB / Hemoglobin Beta Antibody - Western Blot of Mouse Anti-Hemoglobin A (beta chain) Antibody. Lane 1: Molecular Weight Ladder. Lane 2: HbA peptide conjugated to BSA. Lane 3: HbA-2 peptide conjugated to BSA. Lane 4: HbC peptide conjugated to BSA. Lane 5: HbF peptide conjugated to BSA. Lane 6: HbS peptide conjugated to BSA. Load: 50ng per lane. Primary antibody: Anti-HbA antibody at 1µg/mL overnight at 4°C. Secondary antibody: Rabbit Anti-Mouse secondary antibody at 1:40,000 for 30 min at RT. Block: MB-073 for 30 min RT. Predicted/Observed: Reactivity seen in Lane 2 specific to HbA and cross reactivity to HbA-2 seen in Lane 3.
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HBB / Hemoglobin Beta Mouse anti-Human Monoclonal (N-Terminus) (14G2.G11.F11) Antibody
Human
ELISA, WB
Unconjugated
25 µl/$304
HBB / Hemoglobin Beta Antibody - Western blot of recombinant HBB / Hemoglobin Beta.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBB / Hemoglobin Beta Rabbit anti-Sheep Polyclonal (aa1-145) (Biotin) Antibody
Sheep
WB
Biotin Conjugated
100 µl/$349; 200 µl/$409; 500 µl/$611; 1 ml/$763; 2 ml/$1,001; 5 ml/$1,733
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HBB / Hemoglobin Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
HBB / Hemoglobin Beta Antibody - Western Blot of Mouse Anti-Hemoglobin A (beta chain) Antibody. Lane 1: Molecular Weight Ladder. Lane 2: HbA peptide conjugated to BSA. Lane 3: HbA-2 peptide conjugated to BSA. Lane 4: HbC peptide conjugated to BSA. Lane 5: HbF peptide conjugated to BSA. Lane 6: HbS peptide conjugated to BSA. Load: 50ng per lane. Primary antibody: Anti-HbA antibody at 1µg/mL overnight at 4°C. Secondary antibody: Rabbit Anti-Mouse secondary antibody at 1:40,000 for 30 min at RT. Block: MB-073 for 30 min RT. Predicted/Observed: Reactivity seen in Lane 2 specific to HbA and cross reactivity to HbA-2 seen in Lane 3.
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HBB / Hemoglobin Beta Mouse anti-Human Monoclonal (N-Terminus) (14G2.G11.F11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$574
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HBB / Hemoglobin Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
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HBB / Hemoglobin Beta Mouse anti-Chicken Monoclonal (aa1-147) (FITC) Antibody
Chicken
ICC, WB
FITC Conjugated
100 µl/$367; 200 µl/$435; 500 µl/$691; 1 ml/$850; 2 ml/$1,096; 5 ml/$1,961
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HBB / Hemoglobin Beta Mouse anti-Chicken Monoclonal (aa1-147) (Biotin) Antibody
Chicken
ICC, WB
Biotin Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$563; 1 ml/$678; 2 ml/$915; 5 ml/$1,541
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).