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HADHA

hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit

HADHA is the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation.

Gene Name: hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
Synonyms: HADHA, 3-oxoacyl-CoA thiolase, 78 kDa gastrin-binding protein, ECHA, LCEH, LCHAD, GBP, MTPA, TP-ALPHA, Gastrin-binding protein
Target Sequences: NM_000182 NP_000173.2 P40939

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Products
Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
HADHA (4)
No (4)
10His, N-terminus + Myc, C-terminus (1)
GST (1)
Myc-DDK (Flag) (2)
Human (2)
Mouse (1)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (2)
HADHA Protein - 12.5% SDS-PAGE of human HADHA stained with Coomassie Blue
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Wheat Germ Extract
GST
109.4 kDa
2 µg/$439
HADHA Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus + Myc, C-terminus
52.1 kDa
20 µg/$405; 1 mg/$1,679; 100 µg/$598
HADHA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
83 kDa
100 µg/$494
HADHA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
83 kDa
20 µg/$150
Viewing 1-4 of 4 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).