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GRIN2A / NMDAR2A / NR2A

glutamate receptor, ionotropic, N-methyl D-aspartate 2A

GRIN2A / NMDAR2A / NR2A is a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.

Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Family/Subfamily: Ion Channel , Glutamate receptor - ionotropic (NMDA receptor)
Synonyms: GRIN2A, EPND, HNR2A, GluN2A, GluR epsilon 1, NMDA receptor 2A, NMDAR2A, NR2A, NMDA receptor subtype 2A
Target Sequences: NM_000833 NP_000824.1 Q12879

Publications (1)

1
Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease. Jack Hashem, Mei Hu, Jian Zhang, Fei Gao, Chu Chen. Molecular neurobiology. 2021 Aug;;58:4122-4133. [Full Text Article] [PubMed:33939165] [PMC:PMC8282737 (ava] Related Antibodies: LS-B7707.

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Proteins (2)
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GRIN2A / NMDAR2A / NR2A (2)
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6His, N-terminus (2)
Human (2)
E. coli (2)
GRIN2A / NMDAR2A / NR2A Protein - Recombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A By SDS-PAGE
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E. coli
6His, N-terminus
62.5 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
GRIN2A / NMDAR2A / NR2A Protein
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E. coli
6His, N-terminus
31.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).