GPR49 / LGR5

leucine-rich repeat containing G protein-coupled receptor 5

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

GPR49 / LGR5 (6)

Publications

No (6)

Tag

10His, N-terminus + Myc, C-terminus (1)

6His, N-terminus (1)

Fc, C-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Yeast (1)

Purification

Purified (2)

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Human GPR49 / LGR5 Protein (Recombinant 6His, N-terminus) (aa22-561) - LS-G57214

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human GPR49 / LGR5 Protein (Recombinant Fc, C-terminus) - LS-G142236

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Molecular Weight:

38 kDa

Price:

20 µg/$1,107

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Human GPR49 / LGR5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84382

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.8 kDa

Price:

20 µg/$215

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GPR49 / LGR5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100097

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.8 kDa

Price:

100 µg/$710

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Human GPR49 / LGR5 Protein (Recombinant His, N-Terminal) (Lys107-Val296) - LS-G132637

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

25kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human GPR49 / LGR5 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (aa22-561) - LS-G56377

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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