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GNB3

guanine nucleotide binding protein (G protein), beta polypeptide 3

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene Name: guanine nucleotide binding protein (G protein), beta polypeptide 3
Synonyms: GNB3, G protein, beta-3 subunit, Transducin beta chain 3
Target Sequences: NM_002075 NP_002066.1 P16520

Publications (1)

1
Double Cones and the Diverse Connectivity of Photoreceptors and Bipolar Cells in an Avian Retina. Anja Günther, Karin Dedek, Silke Haverkamp, Stephan Irsen, Kevin L Briggman, Henrik Mouritsen. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021 June;41:5015-5028. [Full Text Article] [PubMed:33893221] [PMC:PMC8197639] Related Antibodies: LS-B8347.

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GNB3 ELISA Kit
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0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
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0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$669
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Colorimetric - 450nm (TMB)
1 Plate/$669
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Custom
96-Well Strip Plate
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Colorimetric - 450nm (TMB)
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96-Well Strip Plate
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Colorimetric - 450nm (TMB)
1 Plate/$783
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).