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GLI2

GLI family zinc finger 2

GLI2 is a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.

Gene Name: GLI family zinc finger 2
Synonyms: GLI2, GLI-Kruppel family member GLI2, HPE9, Gli-2, Oncogene GLI2, Tax helper protein 2, THP, Zinc finger protein GLI2, Tax helper protein, THP2, GLI family zinc finger 2, Tax helper protein 1, THP1
Target Sequences: NM_005270 NP_005261.2 P10070

Publications (1)

1
Hedgehog inhibitor sonidegib potentiates (177)Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice. Spetz J, Langen B, Rudqvist N, Parris TZ, Helou K, Nilsson O, Forssell-Aronsson E. BMC cancer. 2017 17:528. (WB; Human) [Full Text Article] [PubMed:28789624] [PMC:PMC5549301] Related Antibodies: LS-C313075.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
GLI2 (6)
No (6)
6His, N-terminus (2)
6His-SUMO, N-terminus (1)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Mammalian Cells (1)
Yeast (1)
Purified (3)
GLI2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
GLI2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Mammalian Cells
6His, N-terminus
100 µg/$1,116; 20 µg/$461; 1 mg/$3,921
GLI2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
GLI2 Protein
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E. coli
His, N-Terminal
40.8 kDa
50 µg/$419
GLI2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
167.6 kDa
20 µg/$215
GLI2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
167.6 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).