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Unfortunately, the antibody LS-C190688 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



GJA1 / CX43 / Connexin 43 Antibodies

gap junction protein, alpha 1, 43kDa

Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5.

Gene Name: gap junction protein, alpha 1, 43kDa
Family/Subfamily: Ion Channel , Connexin
Synonyms: GJA1 Antibody, Connexin-43 Antibody, DFNB38 Antibody, Connexin 43 Antibody, Gap junction alpha-1 protein Antibody, GJAL Antibody, HSS Antibody, Gap junction protein alpha 1 Antibody, ODDD Antibody, ODD Antibody, AVSD3 Antibody, CX43 Antibody, HLHS1 Antibody, ODOD Antibody, SDTY3 Antibody
Target Sequences: NM_000165 NP_000156.1 P17302
 GJA1 / CX43 / Connexin 43 Feature Table
Featured Image

Featured GJA1 / CX43 / Connexin 43 Antibody

LS-A9453 is a rabbit polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.

Publications (1)

1
Connexin 43 controls the multipolar phase of neuronal migration to the cerebral cortex. Liu X, Sun L, Torii M, Rakic P. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:8280-5. [PubMed:22566616] [PMC:PMC3361458] Related Antibodies: LS-C97725.

GJA1 / CX43 / Connexin 43 Antibodies (52)

Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Pig, Rabbit IHC-P C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) IHC-plus™ LS-A9453
IHC Image
Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43
Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Pig, Rabbit
IHC - Paraffin
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Human, Chimpanzee, Gorilla, Chicken IHC-P Internal No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (Internal) IHC-plus™ LS-A9454
IHC Image
Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43
Human, Chimpanzee, Gorilla, Chicken
IHC - Paraffin
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC-P, IF, WB, ELISA aa333-382 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (aa333-382) IHC-plus™ LS-B7595
IHC Image
WB Image
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human, Mouse, Rat
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Goat IgG Polyclonal Unconjugated Rat, Human, Monkey, Mouse, Dog IHC-P, IF, WB C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) IHC-plus™ LS-B9771
IHC Image
IF Image
Goat Polyclonal (IgG) to Rat GJA1 / CX43 / Connexin 43
Rat, Human, Monkey, Mouse, Dog
IHC - Paraffin, Immunofluorescence, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Goat IgG Polyclonal Unconjugated Rat, Human, Monkey, Mouse, Dog IHC-P, IF, WB C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) IHC-plus™ LS-B9770
IHC Image
IF Image
Goat Polyclonal (IgG) to Rat GJA1 / CX43 / Connexin 43
Rat, Human, Monkey, Mouse, Dog
IHC - Paraffin, Immunofluorescence, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC-P, WB Ser367 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (Ser367) IHC-plus™ LS-B1472
IHC Image
WB Image
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Rat, Human, Mouse IHC-P, WB 3rd Cytoplasmic Domain No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (3rd Cytoplasmic Domain) IHC-plus™ LS-B5265
IHC Image
Rabbit Polyclonal (IgG) to Rat GJA1 / CX43 / Connexin 43
Rat, Human, Mouse
IHC - Paraffin, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, IF, WB Ser369 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (Ser369) LS-C175973
IHC Image
WB Image
Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43
Human, Mouse, Rat
IHC, Immunofluorescence, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB pSer367 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (phospho-Ser367) LS-C178044
IHC Image
WB Image
Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43
Human, Mouse, Rat
IHC, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Mouse IgG1 Monoclonal Unconjugated Mouse, Human, Rat, Dog, Pig IHC-Fr, ICC, WB, ELISA aa252-270 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (aa252-270) LS-C14553
Mouse Monoclonal (IgG1) to Mouse GJA1 / CX43 / Connexin 43
Mouse, Human, Rat, Dog, Pig
IHC - Frozen, ICC, Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Human, Mouse IHC, IF, WB Lys257 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (Lys257) LS-C176593
IHC Image
WB Image
Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43
Human, Mouse
IHC, Immunofluorescence, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC-P, WB, ELISA pSer367 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (phospho-Ser367) LS-C117325
WB Image
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Human IHC-P, WB N-Terminus Yes Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (N-Terminus) LS-C97725
PublicationsPublications (1)
IHC Image
WB Image
Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43
Human
IHC - Paraffin, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human IHC, WB No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody LS-C137272
IHC Image
WB Image
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human
IHC, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB Arg361 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (Arg361) LS-C177684
IHC Image
WB Image
Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43
Human, Mouse, Rat
IHC, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human IHC, ELISA pSer261 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (phospho-Ser261) LS-C198823
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human
IHC, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human IF, ELISA aa226-275 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (aa226-275) LS-C117864
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human
Immunofluorescence, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Mouse IHC-P, IHC-Fr, ICC, WB, ELISA aa180-382 No
Anti-GJA1 / CX43 / Connexin 43 Antibody (aa180-382) LS-C293528
Rabbit Polyclonal (IgG) to Mouse GJA1 / CX43 / Connexin 43
Mouse
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human IHC-P, IHC-Fr, ICC, WB, ELISA aa180-382 No
Anti-GJA1 / CX43 / Connexin 43 Antibody (aa180-382) LS-C293525
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Rat IHC-P, IHC-Fr, ICC, WB, ELISA aa180-382 No
Anti-GJA1 / CX43 / Connexin 43 Antibody (aa180-382) LS-C293522
Rabbit Polyclonal (IgG) to Rat GJA1 / CX43 / Connexin 43
Rat
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Rat IHC, ICC, IF, WB aa180-382 No
Anti-GJA1 / CX43 / Connexin 43 Antibody (aa180-382) LS-C301697
Rabbit Polyclonal (IgG) to Rat GJA1 / CX43 / Connexin 43
Rat
IHC, ICC, Immunofluorescence, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC-P, ICC, WB C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) LS-C171543
Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43
Human, Mouse, Rat
IHC - Paraffin, ICC, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Rat IHC, WB, ELISA aa180-382 No
Anti-GJA1 / CX43 / Connexin 43 Antibody (aa180-382) LS-C298016
Rabbit Polyclonal (IgG) to Rat GJA1 / CX43 / Connexin 43
Rat
IHC, Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal FITC Conjugated Human IHC, WB, ELISA N-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (N-Terminus, FITC) LS-C218827
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human
IHC, Western blot, ELISA
FITC Conjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Biotin Conjugated Human IHC, WB, ELISA N-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (N-Terminus, Biotin) LS-C218826
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human
IHC, Western blot, ELISA
Biotin Conjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal PE Conjugated Human IHC, WB, ELISA N-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (N-Terminus, PE) LS-C218833
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human
IHC, Western blot, ELISA
PE Conjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human IHC, WB, ELISA N-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (N-Terminus, Azide-free, HRP) LS-C218828
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human
IHC, Western blot, ELISA
HRP Conjugated, Azide-free
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human IHC-P, WB, ELISA N-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (N-Terminus) LS-C121660
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, ICC, WB C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) LS-C123320
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human, Mouse, Rat
IHC, ICC, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal APC Conjugated Human IHC, WB, ELISA N-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (N-Terminus, APC) LS-C218825
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human
IHC, Western blot, ELISA
APC Conjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal AP Conjugated Human IHC, WB, ELISA N-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (N-Terminus, AP) LS-C218824
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human
IHC, Western blot, ELISA
AP Conjugated
GJA1 / CX43 / Connexin 43 Mouse Monoclonal Unconjugated Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken IHC-Fr, WB C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) LS-C14566
Mouse Monoclonal to Human GJA1 / CX43 / Connexin 43
Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken
IHC - Frozen, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human IHC-P, WB Ser368 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (Ser368) LS-C79740
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human
IHC - Paraffin, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, WB aa366-382 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (aa366-382) LS-C189648
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human, Mouse, Rat
IHC, Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Rat, Human, Mouse IHC-P Cytoplasmic Domain No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (Cytoplasmic Domain) LS-C189354
Rabbit Polyclonal (IgG) to Rat GJA1 / CX43 / Connexin 43
Rat, Human, Mouse
IHC - Paraffin
Unconjugated
GJA1 / CX43 / Connexin 43 Mouse IgG1,k Monoclonal 3E5 Unconjugated Human WB, ELISA No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (clone 3E5) LS-C197296
WB Image
Mouse Monoclonal [clone 3E5] (IgG1,k) to Human GJA1 / CX43 / Connexin 43
Human
Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Goat Polyclonal Unconjugated Human, Gorilla, Gibbon, Monkey, Rat, Bat, Dog, Guinea pig, Pig, Rabbit WB, ELISA No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody LS-C101308
WB Image
Goat Polyclonal to Human GJA1 / CX43 / Connexin 43
Human, Gorilla, Gibbon, Monkey, Rat, Bat, Dog, Guinea pig, Pig, Rabbit
Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Rat, Human, Mouse, Chicken, Xenopus WB C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) LS-C53429
WB Image
Rabbit Polyclonal to Rat GJA1 / CX43 / Connexin 43
Rat, Human, Mouse, Chicken, Xenopus
Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Rat, Human, Mouse, Bovine, Dog, Chicken WB pSer368 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (phospho-Ser368) LS-C53448
WB Image
Rabbit Polyclonal to Rat GJA1 / CX43 / Connexin 43
Rat, Human, Mouse, Bovine, Dog, Chicken
Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Human, Chimpanzee, Gibbon, Monkey, Mouse, Bat, Dog, Guinea pig, Pig, Rabbit WB C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) LS-C110179
WB Image
Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43
Human, Chimpanzee, Gibbon, Monkey, Mouse, Bat, Dog, Guinea pig, Pig, Rabbit
Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human, Chimpanzee, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit WB aa91-140 No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (aa91-140) LS-C30040
WB Image
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human, Chimpanzee, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit
Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat, Bovine, Dog, Guinea pig, Pig, Rabbit, Chicken ELISA aa319-382 No
Anti-GJA1 / CX43 / Connexin 43 Antibody (aa319-382) LS-C311459
Rabbit Polyclonal (IgG) to Human GJA1 / CX43 / Connexin 43
Human, Mouse, Rat, Bovine, Dog, Guinea pig, Pig, Rabbit, Chicken
ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Sepharose Conjugated Human, Mouse, Rat IP C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus, Sepharose) LS-C171545
Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43
Human, Mouse, Rat
Immunoprecipitation
Sepharose Conjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Magnetic beads Conjugated Human, Mouse, Rat IP C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus, Magnetic beads) LS-C171544
Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43
Human, Mouse, Rat
Immunoprecipitation
Magnetic beads Conjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Rat, Human, Mouse 3rd Cytoplasmic Domain No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (3rd Cytoplasmic Domain) LS-C95989
Rabbit Polyclonal to Rat GJA1 / CX43 / Connexin 43
Rat, Human, Mouse
Unconjugated
GJA1 / CX43 / Connexin 43 Mouse IgG1,k Monoclonal Unconjugated Rat, Human, Mouse, Dog IF, WB, ELISA C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) LS-C14557
Mouse Monoclonal (IgG1,k) to Rat GJA1 / CX43 / Connexin 43
Rat, Human, Mouse, Dog
Immunofluorescence, Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Mouse IgG1 Monoclonal Unconjugated Rat, Mouse IF, WB, ELISA No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody LS-C14565
Mouse Monoclonal (IgG1) to Rat GJA1 / CX43 / Connexin 43
Rat, Mouse
Immunofluorescence, Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Mouse WB, ELISA C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) LS-C14563
Rabbit Polyclonal (IgG) to Mouse GJA1 / CX43 / Connexin 43
Mouse
Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Mouse IgM Monoclonal Unconjugated Mouse, Human, Rat, Bovine, Hamster WB, ELISA 2nd Cytoplasmic Domain No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (2nd Cytoplasmic Domain) LS-C14562
Mouse Monoclonal (IgM) to Mouse GJA1 / CX43 / Connexin 43
Mouse, Human, Rat, Bovine, Hamster
Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Mouse WB, ELISA C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) LS-C14554
Rabbit Polyclonal (IgG) to Mouse GJA1 / CX43 / Connexin 43
Mouse
Western blot, ELISA
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit IgG Polyclonal Unconjugated Rat WB C-Terminus No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) LS-C128332
Rabbit Polyclonal (IgG) to Rat GJA1 / CX43 / Connexin 43
Rat
Western blot
Unconjugated
GJA1 / CX43 / Connexin 43 Rabbit Polyclonal Unconjugated Rat, Human, Mouse WB 3rd Cytoplasmic Domain No Primary
Anti-GJA1 / CX43 / Connexin 43 Antibody (3rd Cytoplasmic Domain) LS-C14567
Rabbit Polyclonal to Rat GJA1 / CX43 / Connexin 43
Rat, Human, Mouse
Western blot
Unconjugated

GJA1 / CX43 / Connexin 43 Feature Table


Feature Type Location Details
caution 1 - 382 PubMed:11741837 reported 2 mutations (Phe-11 and Ala-24) linked to non-syndromic autosomal recessive deafness (DFNBG). These mutations have subsequently been shown (PubMed:12457340) to involve the pseudogene of connexin-43 located on chromosome 5.
caution 1 - 382 PubMed:7715640 reported a mutation Pro-364 linked to congenital heart diseases. This was later shown (PubMed:8873667) to be an artifact.
Disease 1 - 382 Defects in GJA1 are a cause of hypoplastic left heart syndrome (HLHS) [MIM:241550]. HLHS refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood flow from the left ventricular outflow tract. In addition, the syndrome includes underdevelopment of the left ventricle, aorta, and aortic arch, as well as mitral atresia or stenosis.
Disease 1 - 382 Defects in GJA1 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD) [MIM:164200]; also known as oculodentoosseous dysplasia. ODDD is a highly penetrant syndrome presenting with craniofacial (ocular, nasal, dental) and limb dysmorphisms, spastic paraplegia, and neurodegeneration. Craniofacial anomalies tipically include a thin nose with hypoplastic alae nasi, small anteverted nares, prominent columnella, and microcephaly. Brittle nails and hair abnormalities of hypotrichosis and slow growth are present. Ocular defects include microphthalmia, microcornea, cataracts, glaucoma, and optic atrophy. Syndactyly type 3 and conductive deafness can occur in some cases. Cardiac abnormalities are observed in rare instances.
Disease 1 - 382 Defects in GJA1 are the cause of autosomal recessive oculodentodigital dysplasia (ODDD autosomal recessive) [MIM:257850].
Disease 1 - 382 Defects in GJA1 may be the cause of syndactyly type 3 (SDTY3) [MIM:186100]. Syndactyly is an autosomal dominant trait and is the most common congenital anomaly of the hand or foot. It is marked by persistence of the webbing between adjacent digits, so they are more or less completely attached. In this type there is usually complete and bilateral syndactyly between the fourth and fifth fingers. Usually it is soft tissue syndactyly but occasionally the distal phalanges are fused. The fifth finger is short with absent or rudimentary middle phalanx. The feet are not affected.
Function 1 - 382 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.
interaction 1 - 382 Q07157:TJP1; NbExp=1; IntAct=EBI-1103439, EBI-79553;
Similarity 1 - 382 Belongs to the connexin family. Alpha-type (group II) subfamily.
Subcellular Location 1 - 382 Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Subunit 1 - 382 A connexon is composed of a hexamer of connexins. Interacts with SGSM3. Interacts with KIAA1432/CIP150. Interacts with CNST.
Tissue Specificity 1 - 382 Expressed in the heart and fetal cochlea.
web resource 1 - 382 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GJA1";
arrayexpress 1 - 382 P17302
bgee 1 - 382 P17302
cleanex 1 - 382 HS_GJA1
ctd 1 - 382 2697
doi 1 - 382 10
drugbank 1 - 382 DB01136
eggnog 1 - 382 prNOG06210
embl 1 - 382 AF151980
embl 1 - 382 AK312324
embl 1 - 382 AL139098
embl 1 - 382 BC026329
embl 1 - 382 CH471051
embl 1 - 382 CR541660
embl 1 - 382 M65188
embl 1 - 382 X52947
ensembl 1 - 382 ENST00000282561
genecards 1 - 382 GC06P121798
geneid 1 - 382 2697
genevestigator 1 - 382 P17302
germonline 1 - 382 ENSG00000152661
go 1 - 382 GO:0004871
go 1 - 382 GO:0005887
go 1 - 382 GO:0005922
go 1 - 382 GO:0006936
go 1 - 382 GO:0007267
go 1 - 382 GO:0015075
go 1 - 382 GO:0016264
go 1 - 382 GO:0030660
go 1 - 382 GO:0043123
go 1 - 382 GO:0045121
h-invdb 1 - 382 HIX0006183
hgnc 1 - 382 HGNC:4274
hogenom 1 - 382 HBG717760
hovergen 1 - 382 HBG009576
hpa 1 - 382 CAB010753
inparanoid 1 - 382 P17302
intact 1 - 382 P17302
interpro 1 - 382 IPR000500
interpro 1 - 382 IPR002261
interpro 1 - 382 IPR013092
interpro 1 - 382 IPR013124
interpro 1 - 382 IPR017990
interpro 1 - 382 IPR019570
ipi 1 - 382 IPI00218487
kegg 1 - 382 hsa:2697
medline 1 - 382 20227707
medline 1 - 382 21617229
medline 1 - 382 22428288
medline 1 - 382 22935763
medline 1 - 382 90338113
medline 1 - 382 91257836
medline 1 - 382 95231557
medline 1 - 382 97027528
medline 1 - 382 97300599
medline 1 - 382 98103681
medline 1 - 382 98104135
mim 1 - 382 121014
mim 1 - 382 164200
mim 1 - 382 186100
mim 1 - 382 241550
mim 1 - 382 257850
mint 1 - 382 MINT-147603
nextbio 1 - 382 10668
oma 1 - 382 TDGANVD
orphanet 1 - 382 1329
orphanet 1 - 382 1330
orphanet 1 - 382 2248
orphanet 1 - 382 2710
orphanet 1 - 382 90025
orphanet 1 - 382 90636
orphanet 1 - 382 93404
orthodb 1 - 382 EOG9D55GZ
panther 1 - 382 PTHR11984
peptideatlas 1 - 382 P17302
pfam 1 - 382 PF00029
pfam 1 - 382 PF03508
pfam 1 - 382 PF10582
pharmgkb 1 - 382 PA28685
phosphosite 1 - 382 P17302
phylomedb 1 - 382 P17302
pir 1 - 382 A35853
pride 1 - 382 P17302
prints 1 - 382 PR00206
prints 1 - 382 PR01132
prosite 1 - 382 PS00407
prosite 1 - 382 PS00408
proteinmodelportal 1 - 382 P17302
pubmed 1 - 382 10581143
pubmed 1 - 382 10764404
pubmed 1 - 382 11470490
pubmed 1 - 382 11741837
pubmed 1 - 382 12457340
pubmed 1 - 382 14574404
pubmed 1 - 382 14702039
pubmed 1 - 382 14702389
pubmed 1 - 382 14729836
pubmed 1 - 382 14974090
pubmed 1 - 382 15108203
pubmed 1 - 382 15489334
pubmed 1 - 382 15637728
pubmed 1 - 382 15757815
pubmed 1 - 382 15978203
pubmed 1 - 382 16112082
pubmed 1 - 382 16219735
pubmed 1 - 382 16222672
pubmed 1 - 382 16378922
pubmed 1 - 382 1646158
pubmed 1 - 382 16709485
pubmed 1 - 382 16813608
pubmed 1 - 382 16816024
pubmed 1 - 382 1696265
pubmed 1 - 382 17509830
pubmed 1 - 382 18083107
pubmed 1 - 382 18161618
pubmed 1 - 382 19338053
pubmed 1 - 382 7715640
pubmed 1 - 382 8873667
pubmed 1 - 382 9155619
pubmed 1 - 382 9430691
pubmed 1 - 382 9443444
reactome 1 - 382 REACT_11123
refseq 1 - 382 NP_000156.1
smart 1 - 382 SM00037
smr 1 - 382 P17302
string 1 - 382 P17302
ucsc 1 - 382 uc003pyr.1
unigene 1 - 382 Hs.74471
chain 2 - 382 Gap junction alpha-1 protein /FTId=PRO_0000057801.
init_met 1 - 1 Removed (By similarity)
Modification 247 - 247 Phosphotyrosine
Modification 262 - 262 Phosphoserine
Modification 306 - 306 Phosphoserine (By similarity)
Modification 313 - 313 Phosphotyrosine
Modification 314 - 314 Phosphoserine (By similarity)
Modification 326 - 326 Phosphothreonine (By similarity)
Modification 328 - 328 Phosphoserine (By similarity)
Modification 330 - 330 Phosphoserine (By similarity)
Modification 365 - 365 Phosphoserine (By similarity)
Modification 368 - 368 Phosphoserine (By similarity)
Modification 369 - 369 Phosphoserine (By similarity)
Modification 373 - 373 Phosphoserine (By similarity)
topo_dom 2 - 13 Cytoplasmic (Potential)
topo_dom 37 - 76 Extracellular (Potential)
topo_dom 100 - 154 Cytoplasmic (Potential)
topo_dom 178 - 208 Extracellular (Potential)
topo_dom 232 - 382 Cytoplasmic (Potential)
transmem 14 - 36 Helical; (Potential)
transmem 77 - 99 Helical; (Potential)
transmem 155 - 177 Helical; (Potential)
transmem 209 - 231 Helical; (Potential)
variant 2 - 2 G -> V (in ODDD) /FTId=VAR_058990.
variant 7 - 7 L -> V (in ODDD) /FTId=VAR_058991.
variant 11 - 11 L -> P (in ODDD) /FTId=VAR_058992.
variant 17 - 17 Y -> S (in ODDD) /FTId=VAR_015747.
variant 18 - 18 S -> P (in ODDD) /FTId=VAR_015748.
variant 21 - 21 G -> R (in ODDD; involvement of only the fourth and fifth fingers; SDTY3). /FTId=VAR_015749.
variant 22 - 22 G -> E (in ODDD; involvement of only the fourth and fifth fingers; SDTY3). /FTId=VAR_015750.
variant 23 - 23 K -> T (in ODDD) /FTId=VAR_015751.
variant 27 - 27 S -> P (in ODDD) /FTId=VAR_038356.
variant 31 - 31 I -> M (in ODDD) /FTId=VAR_038357.
variant 40 - 40 A -> V (in ODDD) /FTId=VAR_015752.
variant 41 - 41 V -> L (in ectodermal and oculodentodigital dysplasia; with skin hyperkeratosis; associated with GJB2 variant His-127). /FTId=VAR_058993.
variant 49 - 49 Q -> K (in ODDD) /FTId=VAR_015753.
variant 49 - 49 Q -> P (in ODDD) /FTId=VAR_058994.
variant 49 - 49 Q -> QQ (in ODDD) /FTId=VAR_058995.
variant 52 - 52 F -> FF (in ODDD) /FTId=VAR_015754.
variant 59 - 59 P -> H (in ODDD) /FTId=VAR_058996.
variant 69 - 69 S -> Y (in ODDD) /FTId=VAR_038358.
variant 76 - 76 R -> H (in Hallermann-Streiff/ODDD) /FTId=VAR_058997.
variant 76 - 76 R -> S (in ODDD) /FTId=VAR_015755.
variant 90 - 90 L -> V (in ODDD) /FTId=VAR_015756.
variant 95 - 95 H -> R (in ODDD) /FTId=VAR_058998.
variant 96 - 96 V -> A (in ODDD) /FTId=VAR_058999.
variant 96 - 96 V -> E (in ODDD) /FTId=VAR_059000.
variant 96 - 96 V -> M (in ODDD; dbSNP:rs28931601) /FTId=VAR_059001.
variant 98 - 98 Y -> C (in ODDD) /FTId=VAR_015757.
variant 102 - 102 K -> N (in ODDD) /FTId=VAR_015758.
variant 106 - 106 L -> P (in ODDD) /FTId=VAR_059002.
variant 110 - 110 E -> D (in ODDD) /FTId=VAR_059003.
variant 113 - 113 L -> P (in ODDD) /FTId=VAR_038359.
variant 124 - 124 D -> E (in dbSNP:rs2228966) /FTId=VAR_014094.
variant 130 - 130 I -> T (in ODDD) /FTId=VAR_015759.
variant 134 - 134 K -> E (in ODDD) /FTId=VAR_015760.
variant 134 - 134 K -> N (in ODDD) /FTId=VAR_038360.
variant 138 - 138 G -> R (in ODDD) /FTId=VAR_015761.
variant 143 - 143 G -> S (in SDTY3; dbSNP:rs28931600) /FTId=VAR_038361.
variant 147 - 147 M -> T (in ODDD) /FTId=VAR_059004.
variant 148 - 148 R -> Q (in dbSNP:rs2228960) /FTId=VAR_014095.
variant 154 - 154 T -> A (in ODDD) /FTId=VAR_059005.
variant 154 - 154 T -> N (in ODDD) /FTId=VAR_059006.
variant 168 - 168 A -> T (in dbSNP:rs2228961) /FTId=VAR_014096.
variant 169 - 169 Missing (in ODDD) /FTId=VAR_059007.
variant 185 - 185 Y -> H (in dbSNP:rs2228962) /FTId=VAR_014097.
variant 194 - 194 H -> P (in ODDD; atypical form of ODDD characterized by the predominance of the ocular involvement and by the absence of hand and/or foot syndactyly and absence of any neurologic signs). /FTId=VAR_059008.
variant 201 - 201 S -> F (in ODDD) /FTId=VAR_059009.
variant 202 - 202 R -> C (in dbSNP:rs2228964) /FTId=VAR_014098.
variant 202 - 202 R -> H (in ODDD) /FTId=VAR_015762.
variant 204 - 204 T -> M (in dbSNP:rs2228965) /FTId=VAR_014099.
variant 216 - 216 V -> L (in ODDD) /FTId=VAR_015763.
variant 220 - 220 S -> Y (in ODDD) /FTId=VAR_059010.
variant 239 - 239 R -> W (in congenital heart malformations; dbSNP:rs2227887). /FTId=VAR_014100.
variant 251 - 251 S -> T (in congenital heart malformations). /FTId=VAR_059011.
variant 253 - 253 A -> P (in congenital heart malformations). /FTId=VAR_059012.
variant 253 - 253 A -> V (in dbSNP:rs17653265) /FTId=VAR_015764.
variant 283 - 283 P -> L (in congenital heart malformations; dbSNP:rs2228974). /FTId=VAR_014101.
variant 290 - 290 T -> N (in congenital heart malformations; dbSNP:rs2227881). /FTId=VAR_014102.
variant 326 - 326 T -> A /FTId=VAR_059013.
variant 352 - 352 E -> G (in heart malformations) /FTId=VAR_059014.
variant 362 - 362 R -> Q (in HLHS; in one individual with atrioventricular septal defect; associated with Gln-376; abolishes phosphorylation by PKA and PKC; dbSNP:rs2227885). /FTId=VAR_032924.
variant 364 - 364 S -> P (in heart malformations; shows abnormalities in the regulation of cell- cell communication as compared with cells expressing normal GJA1). /FTId=VAR_059015.
variant 365 - 365 S -> N (in heart malformations) /FTId=VAR_059016.
variant 373 - 373 S -> G /FTId=VAR_059017.
variant 376 - 376 R -> Q (in HLHS; in one individual with atrioventricular septal defect; associated with Gln-362; abolishes phosphorylation by PKA and PKC). /FTId=VAR_032925.
keyword 1 - 382 Cataract
keyword 1 - 382 Cell junction
keyword 1 - 382 Cell membrane
keyword 1 - 382 Complete proteome
keyword 1 - 382 Disease mutation
keyword 1 - 382 Disulfide bond
keyword 1 - 382 Gap junction
keyword 1 - 382 Membrane
keyword 1 - 382 Phosphoprotein
keyword 1 - 382 Polymorphism
keyword 1 - 382 Transmembrane
keyword 1 - 382 Transmembrane helix
Molecular Weight 1 - 382 43008
1 hit 1 - 382 PF00029
1 hit 1 - 382 PF03508
1 hit 1 - 382 PF10582
1 hit 1 - 382 PS00407
1 hit 1 - 382 PS00408

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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