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FOXP3

forkhead box P3

FOXP3 is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: forkhead box P3
Synonyms: FOXP3, AIID, DIETER, Forkhead box protein P3, JM2, Forkhead box P3, FOXP3delta7, XPID, PIDX, SCURFIN
Target Sequences: NM_014009 NP_054728.2 Q9BZS1

Publications (5)

1
Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells. Ochando JC, Yopp AC, Yang Y, Garin A, Li Y, Boros P, Llodra J, Ding Y, Lira SA, Krieger NR, Bromberg JS. Journal of immunology (Baltimore, Md. : 1950). 2005 174:6993-7005. (IHC) [PubMed:15905542]
2
Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. Lim HW, Hillsamer P, Banham AH, Kim CH. Journal of immunology (Baltimore, Md. : 1950). 2005 175:4180-3. [PubMed:16177055]
3
Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory t cells in the granulomatous lesions. Rahman S, Gudetta B, Fink J, Granath A, Ashenafi S, Aseffa A, Derbew M, Svensson M, Andersson J, Brighenti SG. The American journal of pathology. 2009 174:2211-24. [PubMed:19435796] [PMC:PMC2684186]
4
B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Wilcox RA, Feldman AL, Wada DA, Yang ZZ, Comfere NI, Dong H, Kwon ED, Novak AJ, Markovic SN, Pittelkow MR, Witzig TE, Ansell SM. Blood. 2009 114:2149-58. [PubMed:19597183] [PMC:PMC2744574]
5
Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment. Sang Jun Han , Nuri Sung , Jin Wang, Bert W O'Malley, David M Lonard. Breast cancer research : BCR. 2022 October;24:73. [Full Text Article] [PubMed:36316775] [PMC:PMC9620627] Related Antibodies: LS-C344878.
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Products
Proteins (12)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (4)
Recombinant (7)
FOXP3 (12)
No (12)
6His, N-terminus (1)
GST (1)
His (1)
His, N-Terminal (2)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (5)
Human (9)
Mouse (1)
293T Cells (2)
E. coli (5)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
FOXP3 Protein - Recombinant Forkhead Box Protein P3 By SDS-PAGE
Select
E. coli
His-GST
57.6 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
FOXP3 Protein
Select
E. coli
His, N-Terminal
43.2 kDa
50 µg/$419
FOXP3 Protein - Purified recombinant protein FOXP3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
47.1 kDa
20 µg/$1,107
FOXP3 Protein - Recombinant  Forkhead Box Protein P3 By SDS-PAGE
Select
E. coli
His-T7
29.1 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
FOXP3 Protein
Select
E. coli
His, N-Terminal
46 kDa
10 µg/$265; 200 µg/$484; 50 µg/$315
FOXP3 Protein - 12.5% SDS-PAGE of human FOXP3 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
73.6 kDa
2 µg/$439
FOXP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
43.2 kDa
100 µg/$494
Select
HEK 293 Cells
6His, N-terminus
46 kDa
200 µl/$283
FOXP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
47.1 kDa
100 µg/$710
FOXP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
47.1 kDa
20 µg/$215
FOXP3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
43.2 kDa
20 µg/$150
Select
E. coli
62 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
6.93 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).