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COMP / THBS5

cartilage oligomeric matrix protein

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.

Gene Name: cartilage oligomeric matrix protein
Synonyms: COMP, MED, PSACH, Thrombospondin-5, TSP5, THBS5, EDM1, EPD1
Target Sequences: NM_000095 NP_000086.2 P49747

Publications (1)

1
Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer. Junki Harada, Yasuyoshi Miyata, Kyohei Araki, Tsuyoshi Matsuda, Yoshiaki Nagashima, Yuta Mukae, Kensuke Mistunari, Tomohiro Matsuo, Kojiro Ohba, Yasushi Mochizuki, Hideki Sakai. In Vivo. 2021 April;35:1693-1701. [Full Text Article] [PubMed:33910854] [PMC:PMC8193323] Related Antibodies: LS-B12308.

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ELISA Kits (33)
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Sandwich (21)
Sandwich CLIA (5)
COMP / THBS5 (33)
Human (11)
Mouse (6)
Rat (10)
Chicken (1)
Guinea pig (1)
Horse (1)
Monkey (1)
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Product Group
DevKit DuoPlus (3)
12 x 8-Well Microstrips (3)
96-Well Microplate (6)
96-Well Strip Plate (21)
Antibody Pair and Standard (3)
No (33)
Cell Culture Supernatants (6)
Cell Lysates (5)
EDTA Plasma (1)
Heparin Plasma (1)
Plasma (25)
Serum (26)
Tissue Homogenates (9)
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
COMP / THBS5 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
COMP / THBS5 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$705
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$699
COMP / THBS5 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
COMP / THBS5 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
COMP / THBS5 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Mouse
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
500 Wells/$1,109; 1000 Wells/$1,625
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$798
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$750
COMP / THBS5 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
COMP / THBS5 ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.94 - 60 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
COMP / THBS5 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
0.41 - 300 ng/ml
Chemiluminescent
Plasma, Serum, Tissue Homogenates
1 Plate/$851
COMP / THBS5 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
0.27 - 200 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$911
COMP / THBS5 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
COMP / THBS5 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).