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CASP7 / Caspase 7

caspase 7, apoptosis-related cysteine peptidase

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression.

Gene Name: caspase 7, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP7, Apoptotic protease Mch-3, Caspase 7, Caspase-7, ICE-LAP3, LICE2, MCH3, ICE-like apoptotic protease 3, CASP-7, CMH-1
Target Sequences: NM_001227 NP_001218.1 P55210

Publications (1)

1
Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis. Blanc-Brude OP, Mesri M, Wall NR, Plescia J, Dohi T, Altieri DC. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 9:2683-92. [PubMed:12855648]

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Proteins (27)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (12)
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CASP7 / Caspase 7 (27)
No (27)
6His, N-terminus (2)
GST, N-terminus (2)
His (3)
His, N-Terminal (1)
His-T7 (3)
His-T7, N-terminus (1)
Myc-DDK (Flag) (15)
Human (18)
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E. coli
His, N-Terminal
19.5 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
CASP7 / Caspase 7 Protein - Recombinant Caspase 7 By SDS-PAGE
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E. coli
His-T7
15.1 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
CASP7 / Caspase 7 Protein
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E. coli
His
23.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CASP7 / Caspase 7 Protein - Purified recombinant protein CASP7 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
34.1 kDa
20 µg/$1,107
CASP7 / Caspase 7 Protein - Purified recombinant protein CASP7 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
34.1 kDa
20 µg/$1,107
CASP7 / Caspase 7 Protein - Purified recombinant protein CASP7 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
37.6 kDa
20 µg/$1,107
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E. coli
His
15.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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HEK 293 Cells
6His, N-terminus
35 kDa
200 µl/$283
CASP7 / Caspase 7 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
CASP7 / Caspase 7 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CASP7 / Caspase 7 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
33 kDa
10 µg/$265; 50 µg/$315
CASP7 / Caspase 7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
27.8 kDa
100 µg/$494
CASP7 / Caspase 7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
34.1 kDa
100 µg/$494
CASP7 / Caspase 7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
37.6 kDa
100 µg/$494
CASP7 / Caspase 7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
34.1 kDa
100 µg/$494
CASP7 / Caspase 7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
37.6 kDa
100 µg/$494
CASP7 / Caspase 7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
34.1 kDa
100 µg/$494
CASP7 / Caspase 7 Protein - Recombinant Caspase 7 By SDS-PAGE
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E. coli
His-T7
15.2 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
CASP7 / Caspase 7 Protein - Recombinant Caspase 7 By SDS-PAGE
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E. coli
His-T7
23.5 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
CASP7 / Caspase 7 Protein - Recombinant Caspase 7 (CASP7) by SDS-PAGE
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E. coli
His-T7, N-terminus
31.6kDa
10 µg/$295; 50 µg/$532; 200 µg/$1,049; 100 µg/$850; 1 mg/$2,215; 500 µg/$1,733; 5 mg/$3,711; 2 mg/$2,407
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293T Cells
Myc-DDK (Flag)
34.1 kDa
20 µg/$150
CASP7 / Caspase 7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
34.1 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
37.6 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
34.1 kDa
20 µg/$150
CASP7 / Caspase 7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
37.6 kDa
20 µg/$150
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).