ATR

ataxia telangiectasia and Rad3 related

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

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Products

Proteins (3)

Type

Recombinant (3)

Target

ATR (3)

Publications

No (3)

Tag

GST, N-terminus (1)

His, N-Terminal (1)

His-T7, N-terminus (1)

Species

Human (3)

Source

E. coli (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human ATR Protein (Recombinant His, N-Terminal) (aa2353-2644) - LS-G26069

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

37.4 kDa

Price:

10 µg/$281; 50 µg/$442; 200 µg/$882; 1 mg/$1,989; 5 mg/$3,081; 2 mg/$2,176

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Human ATR Protein (Recombinant GST, N-terminus) (aa2545-2644) - LS-G57863

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ATR Protein (Recombinant His-T7, N-terminus) (Glu25-Tyr214) - LS-G133297

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

25.1kDa

Price:

10 µg/$263; 50 µg/$343; 200 µg/$662; 100 µg/$530; 1 mg/$1,657; 500 µg/$1,242; 5 mg/$2,600; 2 mg/$1,832

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