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Unfortunately, the antibody LS-C110805 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



ABCB11 / BSEP Antibodies

ATP-binding cassette, sub-family B (MDR/TAP), member 11

BSEP (Bile Salt Export Pump) is a liver specific ATP-binding cassette transporter involved in canalicular secretion of bile salts. It has been localized to the canalicular microvilli and to subcanalicular vesicles of hepatocytes by immunogold labeling studies. This protein is mutated in progressive familial intrahepatic cholestasis.

Gene Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Family/Subfamily: Transporter , ATP-binding cassette - ABCB/MDR
Synonyms: ABCB11 Antibody, ABC16 Antibody, Bile salt export pump Antibody, BSEP Antibody, PGY4 Antibody, Sister p-glycoprotein Antibody, BRIC2 Antibody, PFIC-2 Antibody, PFIC2 Antibody, SPGP Antibody
Target Sequences: NM_003742 NP_003733.2 O95342
 ABCB11 / BSEP Feature Table
Featured Image

Featured ABCB11 / BSEP Antibody

LS-B2170 is a mouse monoclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.


ABCB11 / BSEP Antibodies (9)

Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
ABCB11 / BSEP Mouse IgG1 Monoclonal Unconjugated Human, Gorilla, Gibbon IHC-P, ICC, WB aa705-718 No Primary
Anti-ABCB11 / BSEP Antibody (aa705-718) IHC-plus™ LS-B2170
IHC Image
WB Image
Mouse Monoclonal (IgG1) to Human ABCB11 / BSEP
Human, Gorilla, Gibbon
IHC - Paraffin, ICC, Western blot
Unconjugated
ABCB11 / BSEP Rabbit Polyclonal Unconjugated Human, Gorilla, Gibbon ELISA aa1053-1067 No Primary
Anti-ABCB11 / BSEP Antibody (aa1053-1067) LS-C2973
Rabbit Polyclonal to Human ABCB11 / BSEP
Human, Gorilla, Gibbon
ELISA
Unconjugated
ABCB11 / BSEP Rabbit Polyclonal Unconjugated Human, Mouse IHC-P, WB C-Terminus No Primary
Anti-ABCB11 / BSEP Antibody (C-Terminus) LS-C100358
IHC Image
WB Image
Rabbit Polyclonal to Human ABCB11 / BSEP
Human, Mouse
IHC - Paraffin, Western blot
Unconjugated
ABCB11 / BSEP Rabbit IgG Polyclonal FITC Conjugated Human, Mouse IHC, WB, ELISA aa1045-1075 No Primary
Anti-ABCB11 / BSEP Antibody (aa1045-1075, FITC) LS-C243850
Rabbit Polyclonal (IgG) to Human ABCB11 / BSEP
Human, Mouse
IHC, Western blot, ELISA
FITC Conjugated
ABCB11 / BSEP Rabbit IgG Polyclonal PE Conjugated Human, Mouse IHC, WB, ELISA aa1045-1075 No Primary
Anti-ABCB11 / BSEP Antibody (aa1045-1075, PE) LS-C243854
Rabbit Polyclonal (IgG) to Human ABCB11 / BSEP
Human, Mouse
IHC, Western blot, ELISA
PE Conjugated
ABCB11 / BSEP Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human, Mouse IHC, WB, ELISA aa1045-1075 No Primary
Anti-ABCB11 / BSEP Antibody (aa1045-1075, Azide-free, HRP) LS-C247472
Rabbit Polyclonal (IgG) to Human ABCB11 / BSEP
Human, Mouse
IHC, Western blot, ELISA
HRP Conjugated, Azide-free
ABCB11 / BSEP Rabbit IgG Polyclonal APC Conjugated Human, Mouse IHC, WB, ELISA aa1045-1075 No Primary
Anti-ABCB11 / BSEP Antibody (aa1045-1075, APC) LS-C243847
Rabbit Polyclonal (IgG) to Human ABCB11 / BSEP
Human, Mouse
IHC, Western blot, ELISA
APC Conjugated
ABCB11 / BSEP Rabbit IgG Polyclonal Biotin Conjugated Human, Mouse IHC, WB, ELISA aa1045-1075 No Primary
Anti-ABCB11 / BSEP Antibody (aa1045-1075, Biotin) LS-C243848
Rabbit Polyclonal (IgG) to Human ABCB11 / BSEP
Human, Mouse
IHC, Western blot, ELISA
Biotin Conjugated
ABCB11 / BSEP Rabbit IgG Polyclonal AP Conjugated Human, Mouse IHC, WB, ELISA aa1045-1075 No Primary
Anti-ABCB11 / BSEP Antibody (aa1045-1075, AP) LS-C243849
Rabbit Polyclonal (IgG) to Human ABCB11 / BSEP
Human, Mouse
IHC, Western blot, ELISA
AP Conjugated

ABCB11 / BSEP Feature Table


Feature Type Location Details
biophysicochemical properties 1 - 1321 Kinetic parameters: KM=30.4 uM for taurocholate; Vmax=232 pmol/min/mg enzyme for taurocholate transport;
Disease 1 - 1321 Defects in ABCB11 are the cause of benign recurrent intrahepatic cholestasis type 2 (BRIC2) [MIM:605479]. BRIC is characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration and patients are asymptomatic between episodes, both clinically and biochemically.
Disease 1 - 1321 Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis type 2 (PFIC2) [MIM:601847]. PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
domain 1 - 1321 Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
Function 1 - 1321 Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Similarity 1 - 1321 Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Similarity 1 - 1321 Contains 2 ABC transmembrane type-1 domains.
Similarity 1 - 1321 Contains 2 ABC transporter domains.
Subcellular Location 1 - 1321 Membrane; Multi-pass membrane protein.
Subunit 1 - 1321 Interacts with HAX1 (By similarity).
Tissue Specificity 1 - 1321 Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ (By similarity).
web resource 1 - 1321 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ABCB11";
arrayexpress 1 - 1321 O95342
bgee 1 - 1321 O95342
cleanex 1 - 1321 HS_ABCB11
ctd 1 - 1321 8647
doi 1 - 1321 10
drugbank 1 - 1321 DB00171
drugbank 1 - 1321 DB00559
drugbank 1 - 1321 DB01016
eggnog 1 - 1321 prNOG19802
embl 1 - 1321 AC008177
embl 1 - 1321 AC069137
embl 1 - 1321 AC093723
embl 1 - 1321 AF091582
embl 1 - 1321 AF136523
ensembl 1 - 1321 ENST00000263817
genecards 1 - 1321 GC02M169743
geneid 1 - 1321 8647
genevestigator 1 - 1321 O95342
germonline 1 - 1321 ENSG00000073734
go 1 - 1321 GO:0005524
go 1 - 1321 GO:0005624
go 1 - 1321 GO:0005887
go 1 - 1321 GO:0008554
go 1 - 1321 GO:0015432
h-invdb 1 - 1321 HIX0029772
hgnc 1 - 1321 HGNC:42
hogenom 1 - 1321 HBG758042
hovergen 1 - 1321 HBG080809
hpa 1 - 1321 HPA019035
inparanoid 1 - 1321 O95342
interpro 1 - 1321 IPR001140
interpro 1 - 1321 IPR003439
interpro 1 - 1321 IPR003593
interpro 1 - 1321 IPR011527
interpro 1 - 1321 IPR017871
interpro 1 - 1321 IPR017940
ipi 1 - 1321 IPI00184848
kegg 1 - 1321 hsa:8647
medline 1 - 1321 21674594
medline 1 - 1321 21686803
medline 1 - 1321 99021377
mim 1 - 1321 601847
mim 1 - 1321 603201
mim 1 - 1321 605479
nextbio 1 - 1321 32419
oma 1 - 1321 GSYQDSL
orphanet 1 - 1321 172
orphanet 1 - 1321 79304
pfam 1 - 1321 PF00005
pfam 1 - 1321 PF00664
pharmgkb 1 - 1321 PA374
phosphosite 1 - 1321 O95342
phylomedb 1 - 1321 O95342
pride 1 - 1321 O95342
prosite 1 - 1321 PS00211
prosite 1 - 1321 PS50893
prosite 1 - 1321 PS50929
proteinmodelportal 1 - 1321 O95342
pubmed 1 - 1321 10579978
pubmed 1 - 1321 11815775
pubmed 1 - 1321 11829140
pubmed 1 - 1321 15077010
pubmed 1 - 1321 15300568
pubmed 1 - 1321 15815621
pubmed 1 - 1321 16039748
pubmed 1 - 1321 16763017
pubmed 1 - 1321 16799996
pubmed 1 - 1321 17264802
pubmed 1 - 1321 9806540
reactome 1 - 1321 REACT_22258
refseq 1 - 1321 NP_003733.2
smart 1 - 1321 SM00382
string 1 - 1321 O95342
supfam 1 - 1321 SSF90123
tcdb 1 - 1321 3.A.1.201.2
ucsc 1 - 1321 uc002ueo.1
unigene 1 - 1321 Hs.658439
not_annotated_cds; genomic_dna 1 - 1321 -
carbohyd 109 - 109 N-linked (GlcNAc...) (Potential)
carbohyd 116 - 116 N-linked (GlcNAc...) (Potential)
carbohyd 122 - 122 N-linked (GlcNAc...) (Potential)
carbohyd 125 - 125 N-linked (GlcNAc...) (Potential)
chain 1 - 1321 Bile salt export pump /FTId=PRO_0000093296.
conflict 339 - 339 L -> V (in Ref. 1; AAC77455)
domain 62 - 385 ABC transmembrane type-1 1
domain 420 - 656 ABC transporter 1
domain 755 - 1043 ABC transmembrane type-1 2
domain 1078 - 1316 ABC transporter 2
Modification 690 - 690 Phosphoserine (By similarity)
Modification 694 - 694 Phosphoserine (By similarity)
Modification 701 - 701 Phosphoserine (By similarity)
np_bind 455 - 462 ATP 1 (Potential)
np_bind 1113 - 1120 ATP 2 (Potential)
region 651 - 672 Interaction with HAX1 (By similarity)
topo_dom 1 - 62 Cytoplasmic (Potential)
topo_dom 84 - 147 Extracellular (Potential)
topo_dom 169 - 215 Cytoplasmic (Potential)
topo_dom 237 - 240 Extracellular (Potential)
topo_dom 262 - 319 Cytoplasmic (Potential)
topo_dom 341 - 353 Extracellular (Potential)
topo_dom 375 - 755 Cytoplasmic (Potential)
topo_dom 777 - 794 Extracellular (Potential)
topo_dom 816 - 869 Cytoplasmic (Potential)
topo_dom 912 - 979 Cytoplasmic (Potential)
topo_dom 1001 - 1011 Extracellular (Potential)
topo_dom 1033 - 1321 Cytoplasmic (Potential)
transmem 63 - 83 Helical; (Potential)
transmem 148 - 168 Helical; (Potential)
transmem 216 - 236 Helical; (Potential)
transmem 241 - 261 Helical; (Potential)
transmem 320 - 340 Helical; (Potential)
transmem 354 - 374 Helical; (Potential)
transmem 756 - 776 Helical; (Potential)
transmem 795 - 815 Helical; (Potential)
transmem 870 - 890 Helical; (Potential)
transmem 891 - 911 Helical; (Potential)
transmem 980 - 1000 Helical; (Potential)
transmem 1012 - 1032 Helical; (Potential)
variant 56 - 56 S -> L (in dbSNP:rs11568361) /FTId=VAR_055472.
variant 186 - 186 E -> G (in BRIC2) /FTId=VAR_030386.
variant 206 - 206 I -> V (in dbSNP:rs11568357) /FTId=VAR_030387.
variant 238 - 238 G -> V (in PFIC2) /FTId=VAR_030388.
variant 284 - 284 V -> A /FTId=VAR_035349.
variant 284 - 284 V -> L (in PFIC2) /FTId=VAR_013332.
variant 297 - 297 E -> G (in PFIC2 and BRIC2; reduced transport capacity for taurocholate). /FTId=VAR_010271.
variant 299 - 299 R -> K (in dbSNP:rs2287617) /FTId=VAR_030389.
variant 336 - 336 C -> S (in PFIC2) /FTId=VAR_030390.
variant 415 - 415 R -> Q /FTId=VAR_043074.
variant 432 - 432 R -> T (in BRIC2; reduced transport capacity for taurocholate). /FTId=VAR_030391.
variant 444 - 444 V -> A (more frequent in patients with drug-induced cholestasis than healthy controls; associated with lower hepatic expression; does not affect transport capacity for taurocholate; dbSNP:rs2287622). /FTId=VAR_013333.
variant 444 - 444 V -> D (in dbSNP:rs2287622) /FTId=VAR_059106.
variant 444 - 444 V -> G (in dbSNP:rs2287622) /FTId=VAR_059107.
variant 461 - 461 K -> E (in PFIC2) /FTId=VAR_013334.
variant 482 - 482 D -> G (in PFIC2) /FTId=VAR_013335.
variant 570 - 570 A -> T (in BRIC2) /FTId=VAR_030392.
variant 591 - 591 N -> S (in a patient with intrahepatic cholestasis of pregnancy). /FTId=VAR_043075.
variant 616 - 616 R -> G /FTId=VAR_035350.
variant 619 - 619 T -> A /FTId=VAR_035351.
variant 676 - 676 D -> Y (in fluvastatin-induced cholestasis; does not affect transport capacity for taurocholate). /FTId=VAR_043076.
variant 677 - 677 M -> V (does not affect transport capacity for taurocholate; dbSNP:rs11568364). /FTId=VAR_030393.
variant 698 - 698 R -> H /FTId=VAR_035352.
variant 855 - 855 G -> R (in ethinylestradiol/gestodene- induced cholestasis; loss of transport capacity for taurocholate). /FTId=VAR_043077.
variant 865 - 865 A -> V /FTId=VAR_035353.
variant 923 - 923 T -> P (in BRIC2) /FTId=VAR_030394.
variant 926 - 926 A -> P (in BRIC2) /FTId=VAR_030395.
variant 958 - 958 R -> Q /FTId=VAR_035354.
variant 982 - 982 G -> R (in PFIC2) /FTId=VAR_013336.
variant 1004 - 1004 G -> D (in PFIC2) /FTId=VAR_013337.
variant 1050 - 1050 R -> C (in BRIC2) /FTId=VAR_030396.
variant 1128 - 1128 R -> H (in BRIC2) /FTId=VAR_030397.
variant 1153 - 1153 R -> C (in PFIC2) /FTId=VAR_013338.
variant 1186 - 1186 E -> K (in dbSNP:rs1521808) /FTId=VAR_030398.
variant 1268 - 1268 R -> Q (in PFIC2) /FTId=VAR_013339.
keyword 1 - 1321 ATP-binding
keyword 1 - 1321 Complete proteome
keyword 1 - 1321 Disease mutation
keyword 1 - 1321 Glycoprotein
keyword 1 - 1321 Intrahepatic cholestasis
keyword 1 - 1321 Membrane
keyword 1 - 1321 Nucleotide-binding
keyword 1 - 1321 Phosphoprotein
keyword 1 - 1321 Polymorphism
keyword 1 - 1321 Repeat
keyword 1 - 1321 Transmembrane
keyword 1 - 1321 Transmembrane helix
keyword 1 - 1321 Transport
Molecular Weight 1 - 1321 146407
2 hits 1 - 1321 PF00005
2 hits 1 - 1321 PF00664
1 hit 1 - 1321 PS00211
2 hits 1 - 1321 PS50893
2 hits 1 - 1321 PS50929

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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