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Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
Gene Name: | synaptic Ras GTPase activating protein 1 |
Synonyms: | SYNGAP1, KIAA1938, MRD5, SYNGAP, Synaptic Ras-GAP 1, Neuronal RasGAP, RASA5 |
Target Sequences: | NP_006763.2 Q96PV0 |
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