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Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.
Gene Name: | SAM domain and HD domain 1 |
Synonyms: | SAMHD1, AGS5, CHBL2, DCIP, HDDC1, Monocyte protein 5, MOP-5, MOP5, SBBI88, Mg11, SAM domain and HD domain 1 |
Target Sequences: | NM_015474 NP_056289.2 Q9Y3Z3 |
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