Target
Human F5 / Factor Va
Synonyms
F5 | Activated protein C cofactor | Factor V Leiden | FVL | Factor Va | RPRGL1 | THPH2 | Coagulation factor V | PCCF | Proaccelerin, labile factor
Reactivity
Human
(tested or 100% immunogen sequence identity)
Specificity
Human F5 / Factor Va. The defined antibody reactivity is restricted to Factor V, its activated form (Fva) and degradation products. In immunoelectrophoresis, bidimensional electrophoresis, and double radial immunodiffusion (Ouchterlony) against plasma, a single precipitin line is obtained which shows a reaction of identity with the precipitated purified Factor V. No precipitation is obtained with Factor V-depleted plasma and serum. Cross-reactivity The antiserum does not cross-react with any other human plasma proteins as tested in gel-diffusion techniques. Inter-species cross-reactivity is a normal feature of antibodies to plasma proteins, since homologous proteins of different species frequently share antigenic determinants. Cross-reactivity of this antiserum has not been tested in detail, however in double radial immunodiffusion a reaction with Rhesus monkey has been observed.