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Anti-ERBB2 / HER2 Antibody (phospho-Tyr1221/Tyr1222) LS-C190775

Ordering

Wt. Vol. Conc. Price
50 µg - - $485

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Rabbit Polyclonal (IgG) to Human ERBB2 / HER2
Human
Western blot
Unconjugated

Details

Human ERBB2 / HER2
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Affinity purified

Applications

Western blot (1:500 - 1:1000)

Specificity and Use

ERBB2 / HER2 antibody was raised against synthetic phosphopeptide corresponding to human HER2 around the phosphorylation site of tyrosine1221/1222 (N-L-YP-YP -W).
pTyr1221/Tyr1222
Human HER2, phosphorylated at Tyr1221/Tyr1222.

Packaging

PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at 12 months.
For research use only.

About ERBB2 / HER2

P04626 NM_004448 NP_004439.2

ERBB2 Antibody, C-erb B2/neu protein Antibody, CD340 Antibody, HER2 Antibody, Herstatin Antibody, MLN 19 Antibody, HER-2 Antibody, Neu Antibody, NGL Antibody, Proto-oncogene c-ErbB-2 Antibody, Proto-oncogene Neu Antibody, CD340 antigen Antibody, MLN19 Antibody, p185erbB2 Antibody, TKR1 Antibody

A tyrosine kinase receptor in the EGF-receptor family. ErbB2 does not bind ligand on its own, but acts as an amplifier in heterodimers with ErbB1, (EGFR), ErbB3, or ErbB4. Amplification of the ErbB2 gene and overexpression of ErbB2 protein is associated with breast cancer (~25% of cases), and anti-ErbB2 therapeutics (e. g. Herceptin, an anti-ErbB2 monoclonal antibody) are sometimes effective in treating these cases. Overexpression of ErbB2 has also been indicated as a factor in prostate cancer.

Requested From: United States
Date Requested: 7/29/2014
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