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Anti-ERBB2 / HER2 Antibody (aa23-653, clone 12K88) LS-C182844

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Rat Monoclonal [clone 12K88] (IgG1) to Mouse ERBB2 / HER2
Mouse
Flow Cytometry
Unconjugated

Details

Mouse ERBB2 / HER2
Rat
Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [12K88]
Protein A/G purified

Applications

Flow Cytometry

Specificity and Use

ERBB2 / HER2 antibody was raised against recombinant corresponding to aa23-653 from mouse ErbB2 expressed in NSO cell line.
aa23-653
Mouse ERBB2 / HER2

Packaging

Lyophilized from PBS, trehalose
200 µl Sterile PBS
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C.
For research use only.

About ERBB2 / HER2

P04626 NM_004448 NP_004439.2

ERBB2 Antibody, C-erb B2/neu protein Antibody, CD340 Antibody, HER2 Antibody, Herstatin Antibody, MLN 19 Antibody, HER-2 Antibody, Neu Antibody, NGL Antibody, Proto-oncogene c-ErbB-2 Antibody, Proto-oncogene Neu Antibody, CD340 antigen Antibody, MLN19 Antibody, p185erbB2 Antibody, TKR1 Antibody

A tyrosine kinase receptor in the EGF-receptor family. ErbB2 does not bind ligand on its own, but acts as an amplifier in heterodimers with ErbB1, (EGFR), ErbB3, or ErbB4. Amplification of the ErbB2 gene and overexpression of ErbB2 protein is associated with breast cancer (~25% of cases), and anti-ErbB2 therapeutics (e. g. Herceptin, an anti-ErbB2 monoclonal antibody) are sometimes effective in treating these cases. Overexpression of ErbB2 has also been indicated as a factor in prostate cancer.

Requested From: United States
Date Requested: 10/31/2014

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