Human AURKB / Aurora-B

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Purified

Unmodified

Synthetic peptide corresponding to aa227-238 of human Aurora-B kinase.

aa227-238

Detects Aurora-B kinase (AurB), a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis- one containing all four members, and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumors, including primary breast and colon tumor samples. Its expression in tumors seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.

• Western blot (1:250 - 1:1000)
• ELISA (1:2000 - 1:10000)

Western Blot: LS-C42572 detects a band of approximately 39kD in HeLa cell lysates.

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q96GD4 NCBI: NM_004217 NP_004208.2