PD-1 / Fc Chimera Protein (Recombinant)
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| Expression System | Chinese Hamster Ovary |
| Format: | Lyophilized |
$320.00each
Catalog Number: LS-G27024-50
Catalog Number: LS-G27024
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- Description
- Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279) or PDCD1, is a protein that in humans is encoded by the PDCD1 gene. PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells.PD-1 binds two ligands, PD-L1 and PD-L2. PD-1 and its ligands play an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells) Recombinant Human PD-1 produced in CHO cells with C-terminal Fc tag, is a polypeptide chain containing 376 amino acids. A fully biologically active molecule, rhPD-1 has a molecular mass of 60-65 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
- Category
- Proteins & Peptides > Proteins > Recombinant Proteins
Protein
- Expression System
- Chinese Hamster Ovary
- Molecular Weight
- 60-65 kDa (SDS-PAGE)
- Protein Type
- Recombinant
- Amino Acid Sequence
1LDSPDRPWNP PTFSPALLVV TEGDNATFTC SFSNTSESFV LNWYRMSPSN QTDKLAAFPE61DRSQPGQDCR FRVTQLPNGR DFHMSVVRAR RNDSGTYLCG AISLAPKAQI KESLRAELRV121TERRAEVPTA HPSPSPRPAG QFQ
143 aa
Format
- Purity
- >98%
- Conjugate/Label
- Unconjugated
- Endotoxin Level
- < 0.2 EU/µg
- Format
- Lyophilized
- Formulation
- Lyophilized from Sterile Solution PBS
- Purity Measurement Method
- SDS-PAGE (Coomassie Stain)
Storage & Handling
- Storage Conditions
- Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 3 months.