IL21 Antibody
Catalog Number: LS-C187693-0.1
0.1 mg (1 mg/mL) / $523.00
Antibody: Rabbit Polyclonal
Applications: Enzyme-Linked Immunosorbent Assay, Western Blot
Reactivity: Mouse
Format: Lyophilized
Mouse IL21 Protein (Recombinant)
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| Expression System | Escherichia coli (Prokaryotic) |
| Format: | Lyophilized |
$287.00each
Catalog Number: LS-G136252-2
Catalog Number: LS-G136252
For bulk orders or custom formulations:
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- Description
- IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T cell-stimulated B cells into plasma cells and memory B cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naive B cells and stimulated B cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the ? chain (?c) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Murine IL-21 is a 15.0 kDa protein consisting of 130 amino acid residues.
- Category
- Proteins & Peptides > Proteins > Recombinant Proteins
- Alternative Names
- IL21 | Interleukin 21 | Interleukin-21 | Interleukin-21 isoform | Za11 | IL-21
- Origin Species
- Ms
- NCBI GenBank
- NM_021803
- SwissProt
- Q9HBE4
Protein
- Expression System
- E.coli
- Molecular Weight
- 15.0 kDa
- Protein Type
- Recombinant
- Amino Acid Sequence
1MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK61LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL121LQKMIHQHLS
130 aa
Format
- Purity
- >98%
- Conjugate/Label
- Unconj
- Endotoxin Level
- < 0.1 EU/µg
- Format
- Lyophilized
- Formulation
- Lyophilized from sterile filtered 2mM Sodium Citrate, pH 4
- Animal Free
- Yes
- Purity Measurement Method
- SDS-PAGE
Storage & Handling
- Storage Conditions
- Before reconstitution: Short term: Room temperature; Long term: -20°C to -80°C. After reconstitution: Short term: 4°C; Long term: Aliquot and store with a carrier protein at -20°C to -80°C. Avoid freeze thaw cycles. Microcentrifuge before opening.
