Overview

Description

Fibroblast Growth Factor- acidic (FGF-acidic) is a mitogen targeting at the endothelial cells, and belongs to the heparin binding FGF family, which contains 22 members. FGF-acidic binds to the receptor family FGFR1-4 in vivo with the assistance of heparin. However, along with FGF -basic, FGF-acidic lacks the signal peptide segment, and thus is not secreted via endoplasmic reticulum (ER) and Golgi bodies. Studies have shown that FGF-acidic is highly regulated, and it is a direct angiogenesis factor. If unregulated, angiogenesis could contribute to several diseases including arthritis, diabetes, ocular neovascularization, and especially tumors. Therefore, FGF-acidic is treated as a potential oncogene, and its overexpression is correlated tightly with several cancers. Recombinant mouse Fibroblast Growth Factor- acidic (rmFGF-acidic) produced in E. coli is a single non-glycosylated polypeptide chain containing 140 amino acids. A fully biologically active molecule, rmFGF-acidic has a molecular mass of 15.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.

Category

Proteins & Peptides > Proteins > Recombinant Proteins

Gene Name

FGF1

Alternative Names

AFGF | Endothelial cell growth factor | Fibroblast growth factor 1 | FGFA | ECGFB | HBGF-1 | FGF1 | GLIO703 | ECGF | ECGF-beta | ECGFA | FGF-1 | FGF-alpha | HBGF1

Origin Species

Human, Mouse

UniProt Number

P05230

NCBI GenBank

X59065

SwissProt

P05230