TNFSF13 / APRIL Antibody
Catalog Number: LS-C104588
2 sizes / from $364.00
Antibody: Rabbit Polyclonal
Applications: Enzyme-Linked Immunosorbent Assay, Western Blot
Reactivity: Human
Format: Lyophilized
Human TNFSF13 / APRIL Protein (Recombinant His-Flag, C-terminus)
ProteinLSBio Guarantee
| Expression System | Other |
| Format: | Lyophilized |
$294.00each
Catalog Number: LS-G137902-10
Catalog Number: LS-G137902
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- Description
- APRIL(a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL, which consists almost entirely of a single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R. APRIL binds to heparan sulfate proteoglycans (HSPGs) independently of its binding to TACI and BCMA. APRIL can form bioactive heterotrimers with BAFF, and these circulate in the serum of patients with rheumatic immune disorders. APRIL enhances the proliferation and survival of plasma cells and also promotes T cell-dependent humoral responses. APRIL levels are elevated in the serum during coronary artery disease, and it is also elevated in many cancers primarily due to expression by tumor-infiltrating neutrophils.
- Category
- Proteins & Peptides > Proteins > Recombinant Proteins
- Alternative Names
- APRIL | CD256 | CD256 antigen | TALL-2 | TALL2 | ZTNF2 | TNF-related death ligand 1 | TNFSF13 | TRDL-1 | UNQ383/PRO715
- Origin Species
- Hu
- NCBI GenBank
- NM_003808
- SwissProt
- O75888
Protein
- Expression System
- Other
- Fusion Tag
- 6×His, FLAG
- Protein Type
- Recombinant
- Amino Acid Sequence
1DYKDDDDKHH HHHHGPGQVQ LQKKQHSVLH LVPINATSKD DSDVTEVMWQ PALRRGRGLQ61AQGYGVRIQD AGVYLLYSQV LFQDVTFTMG QVVSREGQGR QETLFRCIRS MPSHPDRAYN121SCYSAGVFHL HQGDILSVII PRARAKLNLS PHGTFLGFVK LGGGGSKKQH SVLHLVPINA181TSKDDSDVTE VMWQPALRRG RGLQAQGYGV RIQDAGVYLL YSQVLFQDVT FTMGQVVSRE241GQGRQETLFR CIRSMPSHPD RAYNSCYSAG VFHLHQGDIL SVIIPRARAK LNLSPHGTFL301GFVKLGGGGS KKQHSVLHLV PINATSKDDS DVTEVMWQPA LRRGRGLQAQ GYGVRIQDAG361VYLLYSQVLF QDVTFTMGQV VSREGQGRQE TLFRCIRSMP SHPDRAYNSC YSAGVFHLHQ421GDILSVIIPR ARAKLNLSPH GTFLGFVKL
449 aa
Format
- Purity
- >90%
- Conjugate/Label
- Unconj
- Endotoxin Level
- < 1 EU/µg
- Format
- Lyophilized
- Formulation
- Lyophilized from a sterile solution in PBS, pH 7.4.
- Purity Measurement Method
- SDS-PAGE
Storage & Handling
- Storage Conditions
- Before reconstitution: short term; store at room temperature for up to 3 weeks, long term; store at -20°C. After Reconstitution: short term; store at 4°C to 7°C for up to 7 days, long term; Aliquot and store at -20°C for up to 3 months. Avoid freeze-thaw cycles.
