TMPRSS2 / Epitheliasin Antibody
Catalog Number: LS-C342249
2 sizes / from $364.00
Antibody: Rabbit Polyclonal
Applications: Immunohistochemistry (general), Western Blot
Reactivity: Human, Mouse, Rat
Format: Liquid
Human TMPRSS2 / Epitheliasin Protein (Recombinant 6His, N-terminus)
ProteinLSBio Guarantee
| Expression System | Yeast |
| Format: | Liquid |
$372.00each
Catalog Number: LS-G57269-20
Catalog Number: LS-G57269
For bulk orders or custom formulations:
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- Description
- TMPRSS2 / Epitheliasin Protein LS-G57269 is a Recombinant Human TMPRSS2 / Epitheliasin produced in Yeast aa 106-492 with 6His, N-terminus tag(s). For Research Use Only
- Category
- Proteins & Peptides > Proteins > Recombinant Proteins
- Alternative Names
- Epitheliasin | PRSS10 | Serine protease 10 | PP9284 | TMPRSS2 | host protease for SARS-CoV-2 replication
- Origin Species
- Human
- NCBI GenBank
- NM_005656
- SwissProt
- O15393
Protein
- Expression System
- Yeast
- Fusion Tag
- Hexahistidine Tag
- Protein Type
- Recombinant
- Amino Acid Sequence
1aa 106-492 |WKFMGSKCS NSGIECDSSG TCINPSNWCD GVSHCPGGED ENRCVRLYGP61NFILQVYSSQ RKSWHPVCQD DWNENYGRAA CRDMGYKNNF YSSQGIVDDS GSTSFMKLNT121SAGNVDIYKK LYHSDACSSK AVVSLRCIAC GVNLNSSRQS RIVGGESALP GAWPWQVSLH181VQNVHVCGGS IITPEWIVTA AHCVEKPLNN PWHWTAFAGI LRQSFMFYGA GYQVEKVISH241PNYDSKTKNN DIALMKLQKP LTFNDLVKPV CLPNPGMMLQ PEQLCWISGW GATEEKGKTS301EVLNAAKVLL IETQRCNSRY VYDNLITPAM ICAGFLQGNV DSCQGDSGGP LVTSKNNIWW361LIGDTSWGSG CAKAYRPGVY GNVMVFTDWI YRQMRADG
398 aa
Format
- Purity
- >90%
- Conjugate/Label
- Unconjugated
- Endotoxin Level
- Not Tested
- Format
- Liquid
- Formulation
- Lyophilized from 20mM Tris-HCl, pH 8.0, 0.5M NaCl, 6% Trehalose
- Purity Measurement Method
- SDS-PAGE (Coomassie Stain)
Storage & Handling
- Storage Conditions
- Short term: store at 2°C to 8°C for up to 1 week. Long term: aliquot and store at -20°C to -80°C. Avoid freeze-thaw cycles.
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity10<sup> Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Member of Fraunhofer International Consortium for Anti-Infective Research (iCAIR), Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany12<sup> Discovery Technology Rese. Markus Hoffmann, Heike Hofmann-Winkler, Joan C Smith, Nadine Krüger, Prerna Arora, Lambert K Sørensen, Ole S Søgaard, Jørgen Bo Hasselstrøm, Michael Winkler, Tim Hempel, Lluís Raich, Simon Olsson, Olga Danov, Danny Jonigk, Takashi Yamazoe, Katsura Yamatsuta, Hirotaka Mizuno, Stephan Ludwig, Frank Noé, Mads Kjolby, Armin Braun, Jason M Sheltzer, Stefan Pöhlmann. EBioMedicine. 2021 Mar;;65:103255.
PubMed: 33676899 · PMC: PMC7930809
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry. bioRxiv : the preprint server for biology. 2021 Jul.
PubMed: 33821268 · PMC: PMC8020968
Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties. Tim Hempel , Katarina Elez, Nadine Krüger, Lluís Raich, Jonathan H Shrimp, Olga Danov, Danny Jonigk , Armin Braun, Min Shen, Matthew D Hall, Stefan Pöhlmann , Markus Hoffmann , Frank Noé. Chemical science. 2021 Aug;12:12600-12609.
PubMed: 34703545 · PMC: PMC8494051
