LSBio
Human SELPLG / PSGL-1 / CD162 Protein (Recombinant Fc, C-terminus)

Human SELPLG / PSGL-1 / CD162 Protein (Recombinant Fc, C-terminus)

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Expression SystemOther
Format:Lyophilized
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$283.00each
Catalog Number: LS-G137856-10

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Overview

Description
PSGL-1 (CD162), is a mucintype glycoprotein that plays a key role in leukocyte adhesion. Human PSGL-1 cDNA encodes 412 amino acids (aa). It expressed on neutrophils, monocytes and most lymphocytes. The mature PSGL-1 (aa 42-412) is expressed as a disulfide-linked homodimer that signals intracellularly and promotes integrin activation. PSGL-1 is found on virtually all leukocytes, dendritic cells, platelets, and some endothelial cells. It is primarily responsible for early events in extravasation, especially rolling adhesion of leukocytes to vascular endothelium. Through high affinity, This SLe(x)-type proteoglycanPGSL-1 calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
CD162 antigen | CLA | CD162 | PSGL1 | PSGL-1 | Selectin P ligand | SELPLG
Origin Species
Hu
NCBI GenBank
NM_003006
SwissProt
Q14242

Protein

Expression System
Other
Fusion Tag
hFc
Protein Type
Recombinant
Amino Acid Sequence
1TEYEYLDYDF LPETEPPEML RNSTDTTPLT GPGTPESTTV EPAARRSTGL DAGGAVTELT
61TELANMGNLS TDSAAMEIQT TQPAATEAQT TQPVPTEAQT TPLAATEAQT TRLTATEAQT
121TPLAATEAQT TPPAATEAQT TQPTGLEAQT TAPAAMEAQT TAPAAMEAQT TPPAAMEAQT
181TQTTAMEAQT TAPEATEAQT TQPTATEAQT TPLAAMEALS TEPSATEALS MEPTTKRGLF
241IPFSVSSVTH KGIEGRMDPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE
301VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE
361YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA
421VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ
481KSLSLSPGK

489 aa

Format

Purity
>95%
Conjugate/Label
Unconj
Endotoxin Level
< 1 EU/µg
Format
Lyophilized
Formulation
Lyophilized from a sterile solution in 20 mM Tris, pH 8.0, 150 mM NaCl
Purity Measurement Method
SDS-PAGE

Storage & Handling

Storage Conditions
Before reconstitution: short term; store at room temperature for up to 3 weeks, long term; store at -20°C. After Reconstitution: short term; store at 4°C to 7°C for up to 7 days, long term; Aliquot and store at -20°C for up to 3 months. Avoid freeze-thaw cycles.

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.