ROR1 Antibody
Catalog Number: LS-C332485
2 sizes / from $281.00
Antibody: Rabbit Polyclonal
Applications: Immunohistochemistry (general), Western Blot
Reactivity: Human
Format: Liquid
Human ROR1 Protein (Recombinant Fc, C-terminus)
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| Expression System | Other |
| Format: | Lyophilized |
$253.00each
Catalog Number: LS-G137865-10
Catalog Number: LS-G137865
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- Description
- ROR1,also known as Neurotrophic tyrosine kinase, receptor-related 1, belongs to the ROR subfamily of Tyr protein kinase family,a protein kinase superfamily. It has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. Human ROR1 shares 97% and 58% aa sequence identity with mouse ROR1 and human ROR2, respectively. ROR1 may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. Its Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
- Category
- Proteins & Peptides > Proteins > Recombinant Proteins
- Alternative Names
- DJ537F10.1 | NTRKR1 | Protein tyrosine kinase t-ror1 | ROR1
- Origin Species
- Hu
- NCBI GenBank
- NM_005012
- SwissProt
- Q01973
Protein
- Expression System
- Other
- Fusion Tag
- hFc
- Protein Type
- Recombinant
- Amino Acid Sequence
1QETELSVSAE LVPTSSWNIS SELNKDSYLT LDEPMNNITT SLGQTAELHC KVSGNPPPTI61RWFKNDAPVV QEPRRLSFRS TIYGSRLRIR NLDTTDTGYF QCVATNGKEV VSSTGVLFVK121FGPPPTASPG YSDEYEEDGF CQPYRGIACA RFIGNRTVYM ESLHMQGEIE NQITAAFTMI181GTSSHLSDKC SQFAIPSLCH YAFPYCDETS SVPKPRDLCR DECEILENVL CQTEYIFARS241NPMILMRLKL PNCEDLPQPE SPEAANCIRI GIPMADPINK NHKCYNSTGV DYRGTVSVTK301SGRQCQPWNS QYPHTHTFTA LRFPELNGGH SYCRNPGNQK EAPWCFTLDE NFKSDLCDIP361ACDSKDSKEK NKMEDIEGRM DEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS421RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL481NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS REEMTKNQVS LTCLVKGFYP541SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN601HYTQKSLSLS PGK
613 aa
Format
- Purity
- >95%
- Conjugate/Label
- Unconj
- Endotoxin Level
- < 1 EU/µg
- Format
- Lyophilized
- Formulation
- Lyophilized from a sterile solution in PBS, pH 7.4.
- Purity Measurement Method
- SDS-PAGE
Storage & Handling
- Storage Conditions
- Before reconstitution: short term; store at room temperature for up to 3 weeks, long term; store at -20°C. After Reconstitution: short term; store at 4°C to 7°C for up to 7 days, long term; Aliquot and store at -20°C for up to 3 months. Avoid freeze-thaw cycles.
