LSBio
Human NOG / Noggin Protein (Recombinant)

Human NOG / Noggin Protein (Recombinant)

ProteinLSBio Guarantee
Expression SystemChinese Hamster Ovary
Format:Lyophilized
See all NOG antibodies →
$284.00each
Catalog Number: LS-G27145-10

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Overview

Description
Noggin, also known as NOG, is a homodimeric glycoprotein that bindsto and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors. Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients, regulating cellular responses dependent on the local concentration of the signaling molecule.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
NOG | Symphalangism 1 (proximal) | SYNS1 | SYM1 | Noggin
Origin Species
Hu
NCBI GenBank
NM_005450, NP_005441.1
SwissProt
Q13253

Protein

Expression System
CHO
Molecular Weight
29-31 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR
61PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM
121WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC
181QRRGGQRCGW IPIQYPIISE CKCSC

205 aa

Format

Purity
>95%
Conjugate/Label
Unconj
Endotoxin Level
< 0.2 EU/µg
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.

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