LSBio
Human LTA / TNF Beta Protein (Recombinant)

Human LTA / TNF Beta Protein (Recombinant)

ProteinLSBio Guarantee
Expression SystemEscherichia coli (Prokaryotic)
Format:Lyophilized
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$279.00each
Catalog Number: LS-G27029-10

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Overview

Description
TNF is secreted by macrophages, monocytes, neutrophils, T-cells, NK-cells following their stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-alpha while CD8 cells secrete little or no TNF-alpha. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL2, GM-CSF. TNF-Beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands, and signals through TNFR1 and TNFR2. TNF-Beta is produced by activated T and B lymphocytes, and has similar activities to TNF-a. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. Recombinant Human TNF-Beta produced in E. coli is is a glycosylated polypeptide chain of 172 amino acids. A fully biologically active molecule,rhTNF-Beta has a molecular mass of 18.6 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
Lymphotoxin-alpha | LT-alpha | TNFSF1 | TNF-beta | TNFB | Tumor necrosis factor beta | LT | LTA | TNF Beta
Origin Species
Human
NCBI GenBank
NM_000595|NP_000586.2
SwissProt
P01374

Protein

Expression System
Escherichia coli (Prokaryotic)
Molecular Weight
18.6 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFLQDGFS
61LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQK
121MVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL

172 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
Not Tested
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 3 months.

Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.