LSBio
Human IL18BP Protein (Recombinant)

Human IL18BP Protein (Recombinant)

ProteinLSBio Guarantee
Expression SystemChinese Hamster Ovary
Format:Lyophilized
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$259.00each
Catalog Number: LS-G27228-10

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Overview

Description
Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. It is expressed in heart, lung, placenta and spleen. IL-18BP functions as an inhibitor of the proinflammatory cytokine IL-18. It binds to IL-18, prevents the binding of IL-18 to its receptor, and thus blocks IL-18-induced IFN-gamma production. The complete Ig domain has been shown to mediate the binding and neutralizing properties. IFN-gamma is able to upregulate the expression of IL-18BP, indicating that IL-18 activity is regulated by a feedback mechanism through IL-18BP.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
IL18BPa | Interleukin-18-binding protein | Interleukin 18 binding protein | Tadekinig-alfa | IL-18BP | IL18BP
Origin Species
Human
NCBI GenBank
NM_173042|NP_766630.2
SwissProt
O95998

Protein

Expression System
Chinese Hamster Ovary
Molecular Weight
42-44 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1TPVSQTTTAA TASVRSTKDP CPSQPPVFPA AKQCPALEVT WPEVEVPLNG TLSLSCVACS
61RFPNFSILYW LGNGSFIEHL PGRLWEGSTS RERGSTGTQL CKALVLEQLT PALHSTNFSC
121VLVDPEQVVQ RHVVLAQLWA GLRATLPPTQ EALPSSHSSP QQQG

164 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 0.2 EU/µg
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.

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