IL17A Antibody
Catalog Number: LS-C104427
2 sizes / from $364.00
Antibody: Goat Polyclonal
Applications: Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Western Blot
Reactivity: Human
Format: Lyophilized
Human IL17A Protein (Recombinant His, C-Terminal)
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| Expression System | Chinese Hamster Ovary |
| Format: | Lyophilized |
$284.00each
Catalog Number: LS-G27263-10
Catalog Number: LS-G27263
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- Description
- Interleukin-17A (IL-17A),also known as CTLA-8 and IL-17, is a proinflammatory cytokine belonging to the IL-17 family. It is secreted by Th17 cells, gamma/delta T cells, NK cells and neutrophils. IL-17A signals through IL-17 receptor A in a complex with receptor C or D to regulate NF-kappaB and MAP kinase activities. IL-17A plays important roles in the anti-microbial response and chronic inflammation. It stimulates the production of IL-6, IL-8 and G-CSF in epithelial and endothelial cells, and induces the expression of ICAM-1 in fibroblasts. Clinically, IL-17A has been associated with inflammatory diseases, such as rheumatoid arthritis, psoriasis and multiple sclerosis.Recombinant human Interleukin-17A (rhIL-17A) produced in CHO cells is a glycosylated homodimer chain containing 142 amino acids. A fully biologically active molecule, rhIL-17A has a molecular mass of around 14-22 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
- Category
- Proteins & Peptides > Proteins > Recombinant Proteins
- Alternative Names
- CTLA-8 | CTLA8 | IL17A | Interleukin-17A | Interleukin 17A | IL-17 | IL-17A | IL17
- Origin Species
- Human
- NCBI GenBank
- NM_002190|NP_002181.1
- SwissProt
- Q16552
Protein
- Expression System
- Chinese Hamster Ovary
- Fusion Tag
- Hexahistidine Tag
- Molecular Weight
- 14-22 kDa (SDS-PAGE)
- Protein Type
- Recombinant
- Amino Acid Sequence
1GITIPRNPGC PNSEDKNFPR TVMVNLNIHN RNTNTNPKRS SDYYNRSTSP WNLHRNEDPE61RYPSVIWEAK CRHLGCINAD GNVDYHMNSV PIQQEILVLR REPPHCPNSF RLEKILVSVG121CTCVTPIVHH VAHHHHHH
138 aa
Format
- Purity
- >95%
- Conjugate/Label
- Unconjugated
- Endotoxin Level
- < 0.2 EU/µg
- Format
- Lyophilized
- Formulation
- Lyophilized from PBS
- Purity Measurement Method
- SDS-PAGE (Coomassie Stain)
Storage & Handling
- Storage Conditions
- Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.
