LSBio
Human IFN Gamma / Interferon Gamma Protein (Recombinant)

Biological Activity IFN-gamma, Human induced cytotoxicity of HT-29 (HTB-38) cells. The ED 50 for this effect is less than 0.05ng/mL.

Human IFN Gamma / Interferon Gamma Protein (Recombinant)

ProteinLSBio Guarantee
Expression SystemEscherichia coli (Prokaryotic)
Format:Lyophilized
See all IFNG antibodies →
$250.00each
Catalog Number: LS-G27043-10

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Overview

Description
Human Interferon gamma (hIFN-gamma) is amacrophage-activating factor and the lone member of Interferon type II.The active form of IFN-gamma is an antiparallel dimer that interacts with the receptor IFN-gammaR1 and sets off IFN-gamma/JAK/STAT pathway. IFN-gamma signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. While IFN-gamma-induced inflammatory cascade summons a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers. Recombinant human Interferon gamma (rhIFN-gamma) produced in E. coli is a non-glycosylated polypeptide chain of 144 amino acids. A fully biologically active molecule, rhIFN-gamma has a molecular mass of 17 kDa analyzed by reducing SDS-PAGE and is obtained by refolding and chromatographic techniques.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
IFG | Immune interferon | IFI | Interferon gamma | IFN-gamma | IFNG | Interferon | gamma | IFNY
Origin Species
Human
NCBI GenBank
NM_000619|NP_000610.2
SwissProt
P01579

Protein

Expression System
Escherichia coli (Prokaryotic)
Molecular Weight
17 kDa
Protein Type
Recombinant
Amino Acid Sequence
1MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN
61FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE
121LSPAAKTGKR KRSQMLFRGR RASQ

144 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 1.0 EU/µg
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.

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