LSBio
Rat CD274 / B7-H1 / PD-L1 Protein (Recombinant 6His, C-terminus)

Rat CD274 / B7-H1 / PD-L1 Protein (Recombinant 6His, C-terminus)

ProteinLSBio Guarantee
Expression SystemOther
Format:Lyophilized
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$283.00each
Catalog Number: LS-G137894-10

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Overview

Description
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
B7-H | B7 homolog 1 | B7-H1 | B7H1 | CD274 molecule | CD274 | CD274 antigen | PDCD1 ligand 1 | PDL1 | PD-L1 | PDCD1L1 | PDCD1LG1 | Programmed death ligand 1
Origin Species
Rat
NCBI GenBank
NM_014143
SwissProt
Q9NZQ7

Protein

Expression System
Other
Fusion Tag
Hexahistidine Tag
Protein Type
Recombinant
Amino Acid Sequence
1AFTITAPKDL YVVEYGSNVT MECRFPVEQK LDLLALVVYW EKEDKEVIQF VEGEEDLKPQ
61HSSFRGRAFL PKDQLLKGNA VLQITDVKLQ DAGVYCCMIS YGGADYKRIT LKVNAPYRKI
121NQRISMDPAT SEHELMCQAE GYPEAEVIWT NSDHQSLSGE TTVTTSQTEE KLLNVTSVLR
181VNATANDVFH CTFWRVHSGE NHTAELIIPE LPVPRLPHNR TVDHHHHHH

229 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 1 EU/µg
Format
Lyophilized
Formulation
Lyophilized from a sterile solution in PBS, pH 7.4.
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Before reconstitution: short term; store at room temperature for up to 3 weeks, long term; store at -20°C. After Reconstitution: short term; store at 4°C to 7°C for up to 7 days, long term; Aliquot and store at -20°C for up to 3 months. Avoid freeze-thaw cycles.

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