Soluble Guanylate Cyclase Antibody
Catalog Number: LS-C15634-1
1 mg / $1048.00
Antibody: Mouse Monoclonal
Applications: Enzyme-Linked Immunosorbent Assay, Western Blot
Reactivity: Human
Format: Liquid
Mouse Soluble RANK Ligand (sRANKL) Protein (Recombinant)
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| Expression System | Chinese Hamster Ovary |
| Format: | Lyophilized |
$274.00each
Catalog Number: LS-G133823-2
Catalog Number: LS-G133823
For bulk orders or custom formulations:
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- Description
- RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naive T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant Murine sRANK Ligand is a 19.8 kDa polypeptide comprising the TNF-homologous region of RANKL (178 amino acid residues).
- Category
- Proteins & Peptides > Proteins > Recombinant Proteins
- Origin Species
- Mouse
Protein
- Expression System
- Chinese Hamster Ovary
- Molecular Weight
- 22.1 kda
- Protein Type
- Recombinant
- Amino Acid Sequence
1FSGAPAMMEG SWLDVAQRGK PEAQPFAHLT INAASIPSGS HKVTLSSWYH DRGWAKISNM61TLSNGKLRVN QDGFYYLYAN ICFRHHETSG SVPTDYLQLM VYVVKTSIKI PSSHNLMKGG121STKNWSGNSE FHFYSINVGG FFKLRAGEEI SIQVSNPSLL DPDQDATYFG AFKVQDID
178 aa
Format
- Purity
- >95%
- Conjugate/Label
- Unconjugated
- Endotoxin Level
- <1 EU/μg
- Format
- Lyophilized
- Formulation
- Lyophilized from 0.2 um sterile-filtered solution in 10mM sodium phosphate, 75mM sodium chloride, pH 7.5.
- Purity Measurement Method
- SDS-PAGE (Coomassie Stain)
Storage & Handling
- Storage Conditions
- If lyophilized, can be stored for 1 month at room temperature, 6 months at 4°C, or through the expiration date at -20°C to -80°C. Once reconstituted per the supplied instructions, can be stored for 3 months at -20°C to -80°C, or for 1 week at 2°C to 8°C. Avoid freeze-thaw cycles.
