Overview

Description

R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing the furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in the adrenal glands, ovary, testis, thyroid, and trachea. Rspo can interact with the Frizzled/LRP6 receptor complex in a manner that stimulates the Wnt/beta-catenin signaling pathway. Recombinant Murine R-Spondin-1 is a 27.1 kDa protein consisting of 245 amino acid residues. Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0 kDa by SDS-PAGE analysis under reducing conditions.

Category

Proteins & Peptides > Proteins > Recombinant Proteins

Alternative Names

CRISTIN3 | HRspo1 | R-spondin 1 | Roof plate-specific spondin-1 | RSPONDIN | RSPO | R-spondin-1 | R-spondin1 | RSPO1 | R-spondin homolog | RP11-566C13.1

Origin Species

Mouse

SwissProt

Q2MKA7