MAG Antibody
Catalog Number: LS-C346268
2 sizes / from $281.00
Antibody: Rabbit Polyclonal
Applications: Western Blot
Reactivity: Human, Mouse, Rat
Format: Liquid
Mouse MAG Protein (Recombinant 6His, C-terminus)
ProteinLSBio Guarantee
| Expression System | Other |
| Format: | Lyophilized |
$268.00each
Catalog Number: LS-G137870-10
Catalog Number: LS-G137870
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- Description
- Myelin-Associated Glycoprotein (MAG, Siglec-4a), is a type I transmembrane glycoprotein belonging to the Siglec family. It is composed of an extracellular segment containing five Ig-like domains, a single transmembrane segment, and a cytoplasmic domain. Mouse MAG shares 95% and 99% aa sequence identity with human and rat MAG, respectively. MAG functions as an adhesion molecule during neural development. It preferentially binds to alpha -2,3-linked sialic acid terminal structures found on cell surface molecules. MAG is selectively expressed by myelinating oligodendrocytes and Schwann cells and plays an important role in axon-myelin stability. MAG is also reported to regulate the axon cytoskeleton and support the distribution of axon molecules at the nodes of Ranvier. In addition, it has been identified as a major inhibitor of neurite outgrowth.
- Category
- Proteins & Peptides > Proteins > Recombinant Proteins
- Alternative Names
- GMA | Myelin associated glycoprotein | S-MAG | SIGLEC4A | SIGLEC-4A | MAG | Myelin-associated glycoprotein
- Origin Species
- Mouse
- NCBI GenBank
- NM_002361
- SwissProt
- P20916
Protein
- Expression System
- Other
- Fusion Tag
- Hexahistidine Tag
- Protein Type
- Recombinant
- Amino Acid Sequence
1GHWGAWMPST ISAFEGTCVS IPCRFDFPDE LRPAVVHGVW YFNSPYPKNY PPVVFKSRTQ61VVHESFQGRS RLLGDLGLRN CTLLLSTLSP ELGGKYYFRG DLGGYNQYTF SEHSVLDIVN121TPNIVVPPEV VAGTEVEVSC MVPDNCPELR PELSWLGHEG LGEPTVLGRL REDEGTWVQV181SLLHFVPTRE ANGHRLGCQA AFPNTTLQFE GYASLDVKYP PVIVEMNSSV EAIEGSHVSL241LCGADSNPPP LLTWMRDGMV LREAVAKSLY LDLEEVTPGE DGVYACLAEN AYGQDNRTVE301LSVMYAPWKP TVNGTVVAVE GETVSILCST QSNPDPILTI FKEKQILATV IYESQLQLEL361PAVTPEDDGE YWCVAENQYG QRATAFNLSV EFAPIILLES HCAAARDTVQ CLCVVKSNPE421PSVAFELPSR NVTVNETERE FVYSERSGLL LTSILTIRGQ AQAPPRVICT SRNLYGTQSL481ELPFQGAHRL MWAKIGPHHH HHH
503 aa
Format
- Purity
- >95%
- Conjugate/Label
- Unconjugated
- Endotoxin Level
- < 1 EU/µg
- Format
- Lyophilized
- Formulation
- Lyophilized from a sterile solution in PBS, pH 7.4.
- Purity Measurement Method
- SDS-PAGE (Coomassie Stain)
Storage & Handling
- Storage Conditions
- Before reconstitution: short term; store at room temperature for up to 3 weeks, long term; store at -20°C. After Reconstitution: short term; store at 4°C to 7°C for up to 7 days, long term; Aliquot and store at -20°C for up to 3 months. Avoid freeze-thaw cycles.
