LSBio
Mouse GDNF Protein (Recombinant)

Mouse GDNF Protein (Recombinant)

ProteinLSBio Guarantee
Expression SystemChinese Hamster Ovary
Format:Lyophilized
See all GDNF antibodies →
$284.00each
Catalog Number: LS-G27230-5

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Overview

Description
Glial-Derived Neurotrophic Factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-beta family. It is expressed in both central nervous system (CNS) and non-CNS tissues. GDNF signals through a receptor system composed of a RET and one of the four GFR alpha receptors. It promotes the survival and differentiation of dopaminergic neurons, and increases their high-affinity dopamine uptake. In a mouse Parkinson's Disease model, GDNF has been shown to improve bradykinesia, rigidity, and postural instability. GDNF has also been shown to regulate kidney development, spermatogenesis and affect alcohol consumption.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
HSCR3 | GDNF | HFB1-GDNF | ATF | HGDNF
Origin Species
Mouse
NCBI GenBank
NM_000514|NP_000505.1
SwissProt
P39905

Protein

Expression System
Chinese Hamster Ovary
Molecular Weight
17-22 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET
61KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV
121YHILRKHSAK RCGCI

135 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 0.2 EU/µg
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.

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