LSBio
Mouse F3 / CD142 / Tissue factor Protein (Recombinant 6His, C-terminus)

Mouse F3 / CD142 / Tissue factor Protein (Recombinant 6His, C-terminus)

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Expression SystemOther
Format:Lyophilized
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$328.00each
Catalog Number: LS-G137887-10

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Overview

Description
Tissue Factor, also known as thromboplastin and CD142, belongs to the tissue factor family which conteins 294 amino acid (aa). Mouse TF consists of a signal peptide (residues 1-28) and the mature chain (residues 29-294). It is a single-pass type I membrane protein that expressed in the liver oscillates in a circadian manner. Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
CD142 | CD142 antigen | F3 | TFA | Tissue factor | Thromboplastin | Coagulation factor III
Origin Species
Mouse
NCBI GenBank
NM_001993
SwissProt
P13726

Protein

Expression System
Other
Fusion Tag
Hexahistidine Tag
Protein Type
Recombinant
Amino Acid Sequence
1AGIPEKAFNL TWISTDFKTI LEWQPKPTNY TYTVQISDRS RNWKNKCFST TDTECDLTDE
61IVKDVTWAYE AKVLSVPRRN SVHGDGDQLV IHGEEPPFTN APKFLPYRDT NLGQPVIQQF
121EQDGRKLNVV VKDSLTLVRK NGTFLTLRQV FGKDLGYIIT YRKGSSTGKK TNITNTNEFS
181IDVEEGVSYC FFVQAMIFSR KTNQNSPGSS TVCTEQWKSF LGEHHHHHH

229 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 1 EU/µg
Format
Lyophilized
Formulation
Lyophilized from a sterile solution in 20 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.05% Brij-35
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Before reconstitution: short term; store at room temperature for up to 3 weeks, long term; store at -20°C. After Reconstitution: short term; store at 4°C to 7°C for up to 7 days, long term; Aliquot and store at -20°C for up to 3 months. Avoid freeze-thaw cycles.

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