Overview

Description

MIP-1 alpha/CCL3, also known as LD78 alpha, is an inflammatory chemokine. MIP-1a belongs to the CCL chemokine family, and shares 68% homology with MIP-1beta. The mature form of MIP-1a contains 69 amino acids, exists as dimers in solution, and tends to undergo reversible aggregation. The receptors of MIP-1ain vivo are mainly the G-protein coupled receptors CCR1 and CCR5. Upon stimulation by endogenous and exogenous agents such as Interleukin-1beta, Interferon-gamma, and lipoteichoic acid from gram-positive bacteria, monocytes are able to secrete significant amounts of MIP-1a. MIP-1a augments the adhesions of T lymphocytes, monocytes, and neutrophils to vascular cell adhesion molecule 1. Additionally, in wounds, MIP-1a chemoattracts macrophages in order to accelerate the tissue repair process.Recombinant Mouse MIP-1 alpha/CCL3 (rmMIP-1a) produced in HEK 293cells is a single polypeptide chain containing 69 amino acids. A fully biologically active molecule, rmMIP-1a has a molecular mass of 7.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.

Category

Proteins & Peptides > Proteins > Recombinant Proteins

Alternative Names

C-C motif chemokine 3 | CCL3 | G0S19-1 | Mip1alpha | SCYA3 | SIS-beta | Chemokine (C-C motif) ligand 3 | LD78ALPHA | MIP-1-alpha | MIP1A | PAT 464.1 | Small-inducible cytokine A3

Origin Species

Mouse

NCBI GenBank

NM_002983|NP_002974.1