TNNC1 / Cardiac Troponin C Antibody
Catalog Number: LS-C482323
4 sizes / from $272.00
Antibody: Rabbit Polyclonal
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Reactivity: Human, Mouse, Rat
Format: Liquid
Human TNNC1 / Cardiac Troponin C Protein (Recombinant 6His, N-terminus)
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| Expression System | Escherichia coli (Prokaryotic) |
| Format: | Lyophilized |
$283.00each
Catalog Number: LS-G137911-10
Catalog Number: LS-G137911
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- Description
- Troponin I, also known as TNI, is a 24 kDa component of a protein complex on striated muscle thin filaments.Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Troponin I inhibits the calcium-dependent muscle contraction mediated by Troponins C and T. The expression of cardiac Troponin I (TNNI3) is restricted to cardiac muscle, while TNNI1 and TNNI2 (encoded by distinct genes) are expressed in skeletal muscle. Mutations of cardiac Troponin I are associated with heriditary cardiomyopathy. Human cardiac Troponin I shares 93% amino acid sequence identity with mouse and rat cardiac Troponin I.
- Category
- Proteins & Peptides > Proteins > Recombinant Proteins
- Alternative Names
- CMD1Z | Cardiac troponin C | CMH13 | Troponin C type 1 (slow) | TN-C | TNNC | TNNC1 | Troponin C | slow | Troponin C1
- Origin Species
- Hu
- NCBI GenBank
- NM_003280
- SwissProt
- P63316
Protein
- Expression System
- E.coli
- Fusion Tag
- 6×His
- Protein Type
- Recombinant
- Amino Acid Sequence
1MNHKVHHHHH HMDDIYKAAV EQLTEEQKNE FKAAFDIFVL GAEDGCISTK ELGKVMRMLG61QNPTPEELQE MIDEVDEDGS GTVDFDEFLV MMVRCMKDDS KGKSEEELSD LFRMFDKNAD121GYIDLDELKI MLQATGETIT EDDIEELMKD GDKNNDGRID YDEFLEFMKG VE
172 aa
Format
- Purity
- >95%
- Conjugate/Label
- Unconj
- Endotoxin Level
- < 1 EU/µg
- Format
- Lyophilized
- Formulation
- Sterile solution in 20 mM Tris, pH 8.0, 100 mM NaCl, 1 mM DTT, 10% Glycerol
- Purity Measurement Method
- SDS-PAGE
Storage & Handling
- Storage Conditions
- Store at < -20°C for up to 6 months. Avoid freeze-thaw cycles.
